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dc.creatorWest, Jennifer L.
Masters, Kristyn Simcha
dc.date.accessioned 2015-05-04T19:05:52Z
dc.date.available 2015-05-04T19:05:52Z
dc.date.issued 2010-01-26
dc.identifier.urihttps://hdl.handle.net/1911/80008
dc.description.abstract Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.
dc.format.extent 34 pp
dc.language.iso eng
dc.title Nitric oxide-producing hydrogel materials
dc.type Utility patent
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.
dc.contributor.publisher United States Patent and Trademark Office
dc.type.genre patents
dc.type.dcmi Text
dc.date.filed 2005-11-17
dc.identifier.patentID US7651697B2
dc.contributor.assignee Rice University
dc.identifier.citation West, Jennifer L. and Masters, Kristyn Simcha, "Nitric oxide-producing hydrogel materials." Patent US7651697B2. issued 2010-01-26. Retrieved from https://hdl.handle.net/1911/80008.


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