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    Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein

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    Author
    Olson, John S.; Weiss, Mitchell J.
    Type
    Utility patent
    Abstract
    The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microorganisms, or animal erythroid cells. This intact rHb may then be used as part of a blood substitute product.
    Date
    2010-01-05
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    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892