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dc.creatorScott, Graham B. I.
Kittrell, Carter W.
Curl, Robert F.
Metzker, Michael L.
dc.date.accessioned 2015-05-04T19:05:50Z
dc.date.available 2015-05-04T19:05:50Z
dc.date.issued 2009-03-31
dc.identifier.urihttps://hdl.handle.net/1911/79988
dc.description.abstract The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dispersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
dc.format.extent 28 pp
dc.language.iso eng
dc.title Pulsed-multiline excitation for color-blind fluorescence detection
dc.type Utility patent
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.
dc.contributor.publisher United States Patent and Trademark Office
dc.type.genre patents
dc.type.dcmi Text
dc.date.filed 2005-10-12
dc.identifier.patentID US7511811B2
dc.contributor.assignee Baylor College of Medicine
dc.contributor.assignee Rice University
dc.identifier.citation Scott, Graham B. I., Kittrell, Carter W., Curl, Robert F. and Metzker, Michael L., "Pulsed-multiline excitation for color-blind fluorescence detection." Patent US7511811B2. issued 2009-03-31. Retrieved from https://hdl.handle.net/1911/79988.


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