Carbon nanotubes and their derivatives as matrix elements for the matrix-assisted laser desorption mass spectrometry of biomolecules and sequencing using associated fragmentation
AuthorSivarajan, Ramesh; Hauge, Robert H.; Marriott, Terry
The present invention is directed toward novel matrix elements, generally comprising functionalized carbon nanotubes, for matrix-assisted laser desorption ionization (MALDI)-mass spectroscopy (MS), methods of making such matrix elements, and to methods of using such matrix elements in MALDI-MS applications, particularly for the analysis of biological molecules. In some embodiments, by carefully tuning the absorption characteristics of the matrix element, biomolecular analytes can be sequenced.
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- Rice Patents