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dc.creatorWest, Jennifer L.
Halas, Nancy J.
Oldenburg, Steven J.
Averitt, Richard D.
dc.date.accessioned 2015-05-04T19:05:33Z
dc.date.available 2015-05-04T19:05:33Z
dc.date.issued 2004-03-02
dc.identifier.urihttp://hdl.handle.net/1911/79864
dc.description.abstract The present invention provides nanoshell particles (“nanoshells”) for use in biosensing applications, along with their manner of making and methods of using the nanoshells for in vitro and in vivo detection of chemical and biological analytes, preferably by surface enhanced Raman light scattering. The preferred particles have a non-conducting core and a metal shell surrounding the core. For given core and shell materials, the ratio of the thickness (i.e., radius) of the core to the thickness of the metal shell is determinative of the wavelength of maximum absorbance of the particle. By controlling the relative core and shell thicknesses, biosensing metal nanoshells are fabricated which absorb light at any desired wavelength across the ultraviolet to infrared range of the electromagnetic spectrum. The surface of the particles are capable of inducing an enhanced SERS signal that is characteristic of an analyte of interest. In certain embodiments a biomolecule is conjugated to the metal shell and the SERS signal of a conformational change or a reaction product is detected.
dc.format.extent 20 pp
dc.language.iso eng
dc.title Metal nanoshells for biosensing applications
dc.type Utility patent
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.
dc.contributor.publisher United States Patent and Trademark Office
dc.type.genre patents
dc.type.dcmi Text
dc.date.filed 2000-07-14
dc.identifier.patentID US6699724B1
dc.contributor.assignee Rice University
dc.identifier.citation West, Jennifer L., Halas, Nancy J., Oldenburg, Steven J. and Averitt, Richard D., "Metal nanoshells for biosensing applications." Patent US6699724B1. issued 2004-03-02. Retrieved from http://hdl.handle.net/1911/79864.


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