Now showing items 1-20 of 569

    • Stoichiometric nucleic acid purification using randomer capture probe libraries 

      Zhang, David; Pinto, Alessandro (2022-08-16)
      This disclosure describes a method of purifying several full-length oligonucleotide targets from corresponding synthesis truncation products, in a way that ensures roughly stoichiometric equality among the targets.
    • Regulating electron flow using fragmented proteins 

      Silberg, Jonathan; Atkinson, Joshua T.; Campbell, Ian J.; Bennett, George N. (2022-08-09)
      Engineered protein electron carriers, microorganisms expressing the same, and methods detecting regulated electron flow are described.
    • Hypothermic 3D bioprinting of living tissues supported by perfusable vasculature 

      Miller, Jordan; Ta, Anderson; Grigoryan, Bagrat (2022-06-28)
      The present application is a divisional application of U.S. application Ser. No. 15/709,392, filed Sep. 19, 2017, which is a continuation application of International Application No. PCT/US16/23302, filed Mar. 18, 2016, which claims priority to U.S. Provisional Application No. 62/136,004, filed on Mar. 20, 2015, the contents of which are incorporated ...
    • Use of surface modified porous membranes for fluid distillation 

      Li, Qilin; Wu, Jinjian; Halas, Nancy C.; Zodrow, Katherine R.; Guo, Haoli; (2022-05-17)
      In some embodiments, the present disclosure pertains to systems and methods for distilling a fluid by exposing the fluid to a porous membrane that includes a surface capable of generating heat. In some embodiments, the heat generated at the surface propagates the distilling of the fluid by converting the fluid to a vapor that flows through the porous ...
    • Method for assuring quality of service in distributed storage system, control node, and system 

      Yu, Si; Gong, Junhui; Varman, Peter; Peng, Yuhan (2022-05-03)
      The present disclosure discloses a method for assuring quality of service in a storage system, where a control node calculates, based on a quantity of remaining I/O requests of a target storage node in a unit time, a quantity of I/O requests required by a storage resource to reach a lower assurance limit in the unit time, and a quantity of I/O requests ...
    • Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith 

      Nicolaou, Kyriacos C.; Erande, Rohan Diliprao; Vourloumis, Dionisios; Pulukuri, Kiran Kumar; Rigol, Stephan (2022-03-15)
      In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the ...
    • Methods and systems related to remote measuring and sensing 

      Babakhani, Aydin; Pour, Seyed Mohammad Kazem; Forghani, Mahdi; Sun, Yuxiang; Cherivirala, Yaswanth Kumar (2022-03-01)
      Remote measuring and sensing. Some example embodiment related to optical energy harvesting by identification device, such as infrared identification device GRID devices). Other embodiments relate to RFID device localization using low frequency source signals. Yet still other embodiments related to energy harvesting by RFID in electric fields in both ...
    • Neuronal scaffold-water soluble graphene for treatment of severed spinal cords and neuronal repair 

      Tour, James M.; Sikkema, William (2022-02-15)
      Graphene compositions used for neuronal repair and treatments, and, in particular neuronal scaffold-water soluble graphene for treatment of severed spinal cords and other neuronal repairs. The neuronal scaffold-water soluble graphene can be PEGylated GNR used in combination with a fusogen agent, such as PEG600.
    • Enantiomerically enriched, polycrystalline molecular sieves 

      Davis, Mark E.; Brand, Stephen Kramer; Schmidt, Joel E.; Deem, Michael W. (2021-12-21)
      This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.
    • Electron paramagnetic resonance (EPR) systems and methods for flow assurance and logging 

      Babakhani, Aydin; Yang, Xuebei (2021-12-14)
      An Electron Paramagnetic resonance (EPR) system and method allows the measurement paramagnetic characteristics of materials in real-time, such as heavy oil, hydrocarbons, asphaltenes, heptane, vanadium, resins, drilling fluid, mud, wax deposits or the like. The EPR systems and methods discussed herein are low cost, small and light weight, making them ...
    • Fluorine and hydrogen-based adhesive compositions and methods of making the same 

      Chipara, Alin C.; Chipara, Mircea; Tiwary, Chandra S.; Ajayan, Pulickel M. (2021-11-16)
      Embodiments of the present disclosure pertain to adhesive compositions that include a fluorinated molecule and a hydrogen-containing molecule that are non-covalently associated with one another. The molecules may be non-covalently associated with one another through dipole-dipole interactions that create a fluorine-hydrogen electronegativity difference ...
    • Galactose utilization 

      San, Ka-yiu; Liu, Ping; Li, Sha (2021-11-16)
      The present disclosure describes a genetically engineered bacteria that relieves the catabolite repression problem exerted by the Spot 42 small regulatory RNA by adding a galactokinase that does not contain the Spot 42 binding region. As such, galK (galactokinase) and galM (mutarotase) and the like can be expressed allow better galactose utilization.
    • Lensless imaging system using an image sensor with one or more attenuating layers 

      Sankaranarayanan, Aswin; Veeraraghavan, Ashok; Hendricks, Lisa A.; Baraniuk, Richard; Ayremlou, Ali; (2021-11-16)
      A lens-free imaging system for generating an image of a scene includes an electromagnetic (EM) radiation sensor; a mask disposed between the EM radiation sensor and the scene; an image processor that obtains signals from the EM radiation sensor while the EM radiation sensor is exposed to the scene; and estimates the image of the scene based on, at ...
    • Methods of fabricating laser-induced graphene and compositions thereof 

      Tour, James M.; Chyan, Yieu; Arnusch, Christopher John; Singh, Swatantra Pratap; Li, Yilun; (2021-11-02)
      Methods that expand the properties of laser-induced graphene (LIG) and the resulting LIG having the expanded properties. Methods of fabricating laser-induced graphene from materials, which range from natural, renewable precursors (such as cloth or paper) to high performance polymers (like Kevlar). With multiple lasing, however, highly conductive ...
    • Mechanical opening of lipid bilayers by molecular nanomachines 

      Tour, James M.; Pal, Robert; García-lópez, Victor; Nilewski, Lizanne (2021-10-26)
      Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid ...
    • Universal microbial diagnostics using random DNA probes 

      Drezek, Rebekah A.; Baraniuk, Richard G.; Aghazadeh, Amirali; Sheikh, Mona; Lin, Adam Y.; (2021-08-31)
      The present disclosure is directed to compositions and methods present a universal microbial diagnostic (UMD) platform to screen for microbial organisms in a sample using a small number of random DNA probes that are agnostic to the target DNA sequences. The UMD platform can be used to direct and monitor appropriate treatments, thus minimizing the ...
    • Competitive compositions of nucleic acid molecules for enrichment of rare-allele-bearing species 

      Zhang, David Yu; Wang, Juexiao (2021-08-31)
      The present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a ...
    • Method for determining the composition of natural gas liquids, mean pore-size and tortuosity in a subsurface formation using NMR 

      Vinegar, Harold J.; Singer, Philip M.; Hirasaki, George J.; Chen, Zeliang; Wang, Xinglin (2021-08-24)
      New methods for determining the volumetric composition and saturation of methane and NGLs (natural gas liquids: ethane, propane, butane, and pentane) in a petroleum reservoir combining NMR (nuclear magnetic resonance) logging and NMR core analysis and for determining the mean pore-size and tortuosity of the light hydrocarbon-filled porosity in a ...
    • Carbonaceous nanoparticles as conductivity enhancement additives to water-in-oil emulsions, oil-in-water emulsions and oil-based wellbore fluids 

      Tour, James M.; Ceriotti, Gabriel; Slesarev, Alexander; Ye, Ruquan; Price-hoelscher, Katherine; (2021-08-24)
      Various embodiments of the present disclosure provide methods of making wellbore fluids with enhanced electrical conductivities. In some embodiments, such methods comprise: (1) pre-treating a carbon material with an acid; and (2) adding the carbon material to the wellbore fluid. Further embodiments of the present disclosure pertain to wellbore fluids ...
    • Systems and methods for wireless treatment of arrhythmias 

      Sun, Yuxiang; Babakhani, Aydin; Razavi, Mehdi; Burkland, David; Greet, Brian; (2021-07-27)
      Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device ...