Now showing items 1-6 of 6

    • High molar succinate yield bacteria by increasing the intracellular NADH availability 

      San, Ka-Yiu; Bennett, George N.; Sánchez, Ailen (2011-04-19)
      The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH.
    • Increasing bacterial succinate productivity 

      San, Ka-Yiu; Bennett, George N.; Balzer, Grant; Zhu, Jiang; Thakker, Chandresh; Sánchez, Ailen (2014-08-05)
      Improved bacteria for making succinate and other 4 carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and ...
    • Increasing intracellular NADPH availability in E. coli 

      San, Ka-Yiu; Bennett, George N.; Sánchez, Ailen (2008-02-05)
      A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the ...
    • Mutant E. coli strain with increased succinic acid production 

      San, Ka-Yiu; Bennett, George N.; Sánchez, Ailen (2007-05-29)
      The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.
    • Mutant E. coli strain with increased succinic acid production 

      San, Ka-Yiu; Bennett, George N.; Sánchez, Ailen (2010-09-07)
      The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.
    • Simultaneous anaerobic production of isoamyl acetate and succinic acid 

      San, Ka-Yiu; Sánchez, Ailen; Bennett, George N.; Dittrich, Cheryl Renee (2009-08-04)
      In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in ...