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dc.contributor.authorLamhamedi-Cherradi, Salah-Eddine
Santoro, Marco
Ramammoorthy, Vandhana
Menegaz, Brian A.
Bartholomeusz, Geoffrey
Iles, Lakesla R.
Amin, Hesham M.
Livingston, J. Andrew
Mikos, Antonios G.
Ludwig, Joseph A.
dc.date.accessioned 2015-03-19T15:07:12Z
dc.date.available 2015-03-19T15:07:12Z
dc.date.issued 2014
dc.identifier.citation Lamhamedi-Cherradi, Salah-Eddine, Santoro, Marco, Ramammoorthy, Vandhana, et al.. "3D tissue-engineered model of Ewing's sarcoma." Advanced Drug Delivery Reviews, 79-80, (2014) Elsevier: 155-171. http://dx.doi.org/10.1016/j.addr.2014.07.012.
dc.identifier.urihttps://hdl.handle.net/1911/79384
dc.description.abstract Despite longstanding reliance upon monolayer culture for studying cancer cells, and numerous advantages from both a practical and experimental standpoint, a growing body of evidence suggests that more complex three-dimensional (3D) models are necessary to properly mimic many of the critical hallmarks associated with the oncogenesis, maintenance and spread of Ewing's sarcoma (ES), the second most common pediatric bone tumor. And as clinicians increasingly turn to biologically-targeted therapies that exert their effects not only on the tumor cells themselves, but also on the surrounding extracellular matrix, it is especially important that preclinical models evolve in parallel to reliably measure antineoplastic effects and possible mechanisms of de novo and acquired drug resistance. Herein, we highlight a number of innovative methods used to fabricate biomimetic ES tumors, encompassing both the surrounding cellular milieu and the extracellular matrix (ECM), and suggest potential applications to advance our understanding of ES biology, preclinical drug testing, and personalized medicine.
dc.language.iso eng
dc.publisher Elsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title 3D tissue-engineered model of Ewing's sarcoma
dc.type Journal article
dc.contributor.funder National Cancer Institute
dc.citation.journalTitle Advanced Drug Delivery Reviews
dc.subject.keywordEwing's sarcoma
MCTS
3D
tissue-engineering
scaffolds
ECM
tumor model
preclinical testing
dc.citation.volumeNumber 79-80
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2014.07.012
dc.identifier.pmcid PMC4397982
dc.identifier.pmid 25109853
dc.identifier.grantID RO1 CA151533 (National Cancer Institute)
dc.type.publication publisher version
dc.citation.firstpage 155
dc.citation.lastpage 171


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