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    Tissue engineering perfusable cancer models

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    Author
    Fong, E.L.; Santoro, M.; Farach-Carson, M.C.; Kasper, F.K.; Mikos, A.G.
    Date
    2014
    Abstract
    The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell interactions, effect of interstitial flow on tumor migration and the role of vascular barrier function. To account for the multi-scale nature of cancer growth and invasion, macroscale models are also necessary. The consideration of fluid dynamics within tumor models at both the micro- and macroscopic levels may greatly improve our ability to more fully mimic the tumor microenvironment.
    Citation
    Fong, E.L., Santoro, M., Farach-Carson, M.C., et al.. "Tissue engineering perfusable cancer models." Current Opinion in Chemical Engineering, 3, (2014) Elsevier: 112-117. http://dx.doi.org/10.1016/j.coche.2013.12.008.
    Published Version
    http://dx.doi.org/10.1016/j.coche.2013.12.008
    Keyword
    tissue engineering; cancer; perfusion; tumor models; fluid flow
    Type
    Journal article
    Publisher
    Elsevier
    Citable link to this page
    https://hdl.handle.net/1911/79351
    Rights
    This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
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    • Biochemistry and Cell Biology Publications [118]
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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map