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dc.contributor.authorEkenseair, Adam K.
Boere, Kristel W.M.
Tzouanas, Stephanie N.
Vo, Tiffany N.
Kasper, F. Kurtis
Mikos, Antonios G.
dc.date.accessioned 2015-01-06T15:49:12Z
dc.date.available 2015-01-06T15:49:12Z
dc.date.issued 2012
dc.identifier.citation Ekenseair, Adam K., Boere, Kristel W.M., Tzouanas, Stephanie N., et al.. "Structure-Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering." Biomacromolecules, 13, no. 9 (2012) American Chemical Society: 2821-2830. http://dx.doi.org/10.1021/bm300797m.
dc.identifier.urihttps://hdl.handle.net/1911/78881
dc.description.abstract The impact of synthesis and solution formulation parameters on the swelling and mechanical properties of a novel class of thermally and chemically gelling hydrogels combining poly(N-isopropylacrylamide)-based thermogelling macromers containing pendant epoxy rings with polyamidoamine-based hydrophilic and degradable diamine cross-linking macromers was evaluated. Through variation of network hydrophilicity and capacity for chain rearrangement, the often problematic tendency of thermogelling hydrogels to undergo significant syneresis was addressed. The demonstrated ability to tune postformation dimensional stability easily at both the synthesis and formulation stages represents a significant novel contribution toward efforts to utilize poly(N-isopropylacrylamide)-based polymers as injectable biomaterials. Furthermore, the cytocompatibility of the hydrogel system under relevant conditions was established while demonstrating time- and dose-dependent cytotoxicity at high solution osmolality. Such injectable in situ forming degradable hydrogels with tunable water content are promising candidates for many tissue-engineering applications, particularly for cell delivery to promote rapid tissue regeneration in non-load-bearing defects.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Structure-Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Biomacromolecules
dc.subject.keywordpoly(N-isopropylacrylamide)
polyamidoamine
tissue engineering
injectable
hydrogel
dc.citation.volumeNumber 13
dc.citation.issueNumber 9
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/bm300797m
dc.identifier.pmcid PMC3448273
dc.identifier.pmid 22881074
dc.identifier.grantID R01 DE17441 (National Institutes of Health)
dc.identifier.grantID T32 DE018380 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 2821
dc.citation.lastpage 2830


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