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dc.contributor.authorCorr, Stuart J.
Raoof, Mustafa
Mackeyev, Yuri
Phounsavath, Sophia
Cheney, Matthew A.
Cisneros, Brandon T.
Shur, Michael
Gozin, Michael
McNally, Patrick J.
Wilson, Lon J.
Curley, Steven A.
dc.date.accessioned 2015-01-05T20:03:21Z
dc.date.available 2015-01-05T20:03:21Z
dc.date.issued 2012
dc.identifier.citation Corr, Stuart J., Raoof, Mustafa, Mackeyev, Yuri, et al.. "Citrate-Capped Gold Nanoparticle Electrophoretic Heat Production in Response to a Time-Varying Radio-Frequency Electric Field." The Journal of Physical Chemistry C, 116, no. 45 (2012) American Chemical Society: 24380-24389. http://dx.doi.org/10.1021/jp309053z.
dc.identifier.urihttps://hdl.handle.net/1911/78852
dc.description.abstract The evaluation of heat production from gold nanoparticles (AuNPs) irradiated with radio-frequency (RF) energy has been problematic due to Joule heating of their background ionic buffer suspensions. Insights into the physical heating mechanism of nanomaterials under RF excitations must be obtained if they are to have applications in fields such as nanoparticle-targeted hyperthermia for cancer therapy. By developing a purification protocol that allows for highly stable and concentrated solutions of citrate-capped AuNPs to be suspended in high-resistivity water, we show herein, for the first time, that heat production is only evident for AuNPs of diameters ≤10 nm, indicating a unique size-dependent heating behavior not previously observed. Heat production has also shown to be linearly dependent on both AuNP concentration and total surface area and was severely attenuated upon AuNP aggregation. These relationships have been further validated using permittivity analysis across a frequency range of 10 MHz–3 GHz as well as static conductivity measurements. Theoretical evaluations suggest that the heating mechanism can be modeled by the electrophoretic oscillation of charged AuNPs across finite length scales in response to a time-varying electric field. It is anticipated these results will assist future development of nanoparticle-assisted heat production by RF fields for applications such as targeted cancer hyperthermia.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Citrate-Capped Gold Nanoparticle Electrophoretic Heat Production in Response to a Time-Varying Radio-Frequency Electric Field
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.contributor.funder V Foundation
dc.contributor.funder Welch Foundation
dc.contributor.funder Kanzius Research Foundation
dc.citation.journalTitle The Journal of Physical Chemistry C
dc.contributor.org Smalley Institute for Nanoscale Science and Technology
dc.subject.keywordradiofrequency
gold
nanoparticles
heating
permittivity
dc.citation.volumeNumber 116
dc.citation.issueNumber 45
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/jp309053z
dc.identifier.pmcid PMC3686525
dc.identifier.pmid 23795228
dc.identifier.grantID U54CA143837 (National Institutes of Health)
dc.identifier.grantID CA016672 (National Institutes of Health)
dc.identifier.grantID C-0627 (Welch Foundation)
dc.identifier.grantID Kanzius Research Foundation
dc.type.publication post-print
dc.citation.firstpage 24380
dc.citation.lastpage 24389


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