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dc.contributor.authorHan, Pu
Niestemski, Liang Ren
Barrick, Jeffrey E.
Deem, Michael W.
dc.date.accessioned 2014-12-15T20:35:09Z
dc.date.available 2014-12-15T20:35:09Z
dc.date.issued 2013
dc.identifier.citation Han, Pu, Niestemski, Liang Ren, Barrick, Jeffrey E., et al.. "Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system." Physical Biology, 10, no. 2 (2013) IOP Publishing: 25004. http://dx.doi.org/10.1088/1478-3975/10/2/025004.
dc.identifier.urihttps://hdl.handle.net/1911/78754
dc.description.abstract Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called "spacers" into its CRISPR system. Spacers in the CRISPR system provide a record of the history of bacteria and phage coevolution. We use a physical model to study the dynamics of this coevolution as it evolves stochastically over time. We focus on the impact of mutation and recombination on bacteria and phage evolution and evasion. We discuss the effect of different spacer deletion mechanisms on the coevolutionary dynamics. We make predictions about bacteria and phage population growth, spacer diversity within the CRISPR locus, and spacer protection against the phage population.
dc.language.iso eng
dc.publisher IOP Publishing
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.
dc.title Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Physical Biology
dc.citation.volumeNumber 10
dc.citation.issueNumber 2
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1088/1478-3975/10/2/025004
dc.identifier.pmcid PMC3652287
dc.identifier.pmid 23492852
dc.identifier.grantID 1 R01 GM100468?01 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 25004


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