Now showing items 1-6 of 6
Stability of the hybrid epithelial/mesenchymal phenotype
(Impact Journals, LLC, 2016)
Epithelial-to-Mesenchymal Transition (EMT) and its reverse - Mesenchymal to Epithelial Transition (MET) - are hallmarks of cellular plasticity during embryonic development and cancer metastasis. During EMT, epithelial cells ...
OVOL guides the epithelial-hybrid-mesenchymal transition
(Impact Journals, LLC, 2015)
Metastasis involves multiple cycles of Epithelial-to-Mesenchymal Transition (EMT) and its reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that has maximum ...
Distinguishing mechanisms underlying EMT tristability
(Springer International Publishing, 2017)
Abstract Background The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue ...
Interrogating the topological robustness of gene regulatory circuits by randomization
(Public Library of Science, 2017)
One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example, cell-fate decision-making and signal transduction, through multiple ...
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
(Frontiers Media S.A., 2015)
Transitions between epithelial and mesenchymal phenotypes - the epithelial to -mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition (MET) - are hallmarks of cancer metastasis. While ...
Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model
(Impact Journals, LLC., 2015)
Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal Transition (EMT), and tumor-initiation requires ...