Now showing items 1-5 of 5
The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition
(Nature Publishing Group, 2014)
Metastatic carcinoma cells exhibit at least two different phenotypes of motility and invasion - amoeboid and mesenchymal. This plasticity poses a major clinical challenge for treating metastasis, while its underlying ...
Distinguishing mechanisms underlying EMT tristability
(Springer International Publishing, 2017)
Abstract Background The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue ...
Interrogating the topological robustness of gene regulatory circuits by randomization
(Public Library of Science, 2017)
One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example, cell-fate decision-making and signal transduction, through multiple ...
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
(Frontiers Media S.A., 2015)
Transitions between epithelial and mesenchymal phenotypes - the epithelial to -mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition (MET) - are hallmarks of cancer metastasis. While ...
Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis
(Macmillan Publishers Limited, 2015)
Cellular plasticity during cancer metastasis is a major clinical challenge. Two key cellular plasticity mechanisms —Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Amoeboid Transition (MAT) – have been carefully ...