Now showing items 1-5 of 5
Interrogating the topological robustness of gene regulatory circuits by randomization
(Public Library of Science, 2017)
One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example, cell-fate decision-making and signal transduction, through multiple ...
RACIPE: a computational tool for modeling gene regulatory circuits using randomization
(Springer Nature, 2018)
BACKGROUND: One of the major challenges in traditional mathematical modeling of gene regulatory circuits is the insufficient knowledge of kinetic parameters. These parameters are often inferred from existing experimental ...
Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma
(Impact Journals, 2018)
Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthesis. Understanding the metabolic reprogramming ...
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
(Frontiers Media S.A., 2015)
Transitions between epithelial and mesenchymal phenotypes - the epithelial to -mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition (MET) - are hallmarks of cancer metastasis. While ...
Distinguishing mechanisms underlying EMT tristability
(Springer International Publishing, 2017)
Abstract Background The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue ...