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    How input noise limits biochemical sensing in ultrasensitive systems

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    Author
    Hu, Bo; Rappel, Wouter-Jan; Levine, Herbert
    Date
    2014
    Abstract
    Many biological processes are regulated by molecular devices that respond in an ultrasensitive fashion to upstream signals. An important question is whether such ultrasensitivity improves or limits its ability to read out the (noisy) input stimuli. Here, we develop a simple model to study the statistical properties of ultrasensitive signaling systems. We demonstrate that the output sensory noise is always bounded, in contrast to earlier theories using the small noise approximation, which tends to overestimate the impact of noise in ultrasensitive pathways. Our analysis also shows that the apparent sensitivity of the system is ultimately constrained by the input signal-to-noise ratio. Thus, ultrasensitivity can improve the precision of biochemical sensing only to a finite extent. This corresponds to a new limit for ultrasensitive signaling systems, which is strictly tighter than the Berg-Purcell limit.
    Citation
    Hu, Bo, Rappel, Wouter-Jan and Levine, Herbert. "How input noise limits biochemical sensing in ultrasensitive systems." Physical Review E, 90, (2014) American Physical Society: 32702. http://dx.doi.org/10.1103/PhysRevE.90.032702.
    Published Version
    http://dx.doi.org/10.1103/PhysRevE.90.032702
    Type
    Journal article
    Publisher
    American Physical Society
    Citable link to this page
    https://hdl.handle.net/1911/77670
    Rights
    Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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    • Faculty Publications [4976]
    • Physics and Astronomy Publications [1769]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map