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dc.contributor.authorFouad, Anthony
Pfefer, T. Joshua
Chen, Chao-Wei
Gong, Wei
Agrawal, Anant
Tomlins, Peter H.
Woolliams, Peter D.
Drezek, Rebekah A.
Chen, Yu
dc.date.accessioned 2014-10-09T15:38:24Z
dc.date.available 2014-10-09T15:38:24Z
dc.date.issued 2014
dc.identifier.citation Fouad, Anthony, Pfefer, T. Joshua, Chen, Chao-Wei, et al.. "Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison." Biomedical Optics Express, 5, no. 7 (2014) Optical Society of America: 2066-2081. http://dx.doi.org/10.1364/BOE.5.002066.
dc.identifier.urihttps://hdl.handle.net/1911/77502
dc.description.abstract Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across image volumes in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, 400-nm-diameter iron oxide particles and 1.5-micron-diameter silica particles. The OCT systems included spectral-domain and swept source systems in free-beam geometries as well as a time-domain system in both free-beam and fiberoptic probe geometries. Results indicated that iron oxide particles and gold nanoshells were most effective for measuring spatial variations in the magnitude and shape of PSFs across the image volume. The intensity of individual particles was also used to evaluate spatial variations in signal intensity uniformity. Significant system-to-system differences in resolution and signal intensity and their spatial variation were readily quantified. The phantoms proved useful for identification and characterization of irregularities such as astigmatism. Our multi-system results provide evidence of the practical utility of PSF-phantom-based test methods for quantitative inter-comparison of OCT system resolution and signal uniformity.
dc.language.iso eng
dc.publisher Optical Society of America
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison
dc.type Journal article
dc.contributor.funder National Science Foundation/U.S. Food and Drug Administration
dc.citation.journalTitle Biomedical Optics Express
dc.citation.volumeNumber 5
dc.citation.issueNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1364/BOE.5.002066
dc.identifier.pmcid PMC4102349
dc.identifier.pmid 25071949
dc.identifier.grantID Scholar in Residence Program CBET 1135514 (National Science Foundation/U.S. Food and Drug Administration)
dc.type.publication publisher version
dc.citation.firstpage 2066
dc.citation.lastpage 2081


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