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dc.contributor.authorLevine, Herbert
Rappel, Wouter-Jan
dc.date.accessioned 2014-10-08T21:25:34Z
dc.date.available 2014-10-08T21:25:34Z
dc.date.issued 2013
dc.identifier.citation Levine, Herbert and Rappel, Wouter-Jan. "The physics of eukaryotic chemotaxis." Physics Today, 66, no. 2 (2013) AIP Publishing LLC: 24-30. http://dx.doi.org/10.1063/PT.3.1884.
dc.identifier.urihttps://hdl.handle.net/1911/77450
dc.description.abstract A small scratch on the skin can be quite painful. Fortunately, the pain is transitory and dissipates quickly once the wound heals. The healing process is facilitated by neutrophils, a type of white blood cell that removes bacteria and other foreign materials from a wound. Neutrophils normally reside in your circulatory system but, when needed, are able to leave the bloodstream and efficiently navigate through connective tissue to the injured area. How do they figure out where to go? The answer is chemotaxis, the process of cells following chemical gradients. In addition to wound healing, chemotaxis is important to many other biological processes. Chemical information can help sperm find the egg cell during fertilization. In embryonic development, cells are often directed to their proper location through gradients. Chemotaxis can also aid the spread of cancer during metastasis, the process by which cells leave the primary tumor and seed new tumors in other parts of the body. Experiments have shown that gradients of growth factors guide an initial step in the metastatic process; that step involves the movement of malignant cells away from the tumor and toward blood vessels.
dc.language.iso eng
dc.publisher AIP Publishing LLC
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title The physics of eukaryotic chemotaxis
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Physics Today
dc.citation.volumeNumber 66
dc.citation.issueNumber 2
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1063/PT.3.1884
dc.identifier.pmcid PMC3867297
dc.identifier.pmid 24363460
dc.type.publication publisher version
dc.citation.firstpage 24
dc.citation.lastpage 30


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