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    Malaria Theranostics using Hemozoin-Generated Vapor Nanobubbles

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    Author
    Lukianova-Hleb, Ekaterina Y.; Lapotko, Dmitri O.
    Date
    2014
    Abstract
    Malaria remains a widespread and deadly infectious human disease, with increasing diagnostic and therapeutic challenges due to the drug resistance and aggressiveness of malaria infection. Early detection and innovative approaches for parasite destruction are needed. The high optical absorbance and nano-size of hemozoin crystals have been exploited to detect and mechanically destroy the malaria parasite in a single theranostic procedure. Transient vapor nanobubbles are generated around hemozoin crystals in malaria parasites in infected erythrocytes in response to a single short laser pulse. Optical scattering signals of the nanobubble report the presence of the malaria parasite. The mechanical impact of the same nanobubble physically destroys the parasite in nanoseconds in a drug-free manner. Laser-induced nanobubble treatment of human blood in vitro results in destruction of up to 95% of parasites after a single procedure, and delivers an 8-fold better parasiticidal efficacy compared to standard chloroquine drug treatment. The mechanism of destruction is highly selective for malaria infected red cells and does not harm neighboring, uninfected erythrocytes. Thus, laser pulse-induced vapor nanobubble generation around hemozoin supports both rapid and highly specific detection and destruction of malaria parasites in one theranostic procedure.
    Citation
    Lukianova-Hleb, Ekaterina Y. and Lapotko, Dmitri O.. "Malaria Theranostics using Hemozoin-Generated Vapor Nanobubbles." Theranostics, 4, no. 7 (2014) Ivyspring: 761-769. http://dx.doi.org/10.7150/thno.9128.
    Published Version
    http://dx.doi.org/10.7150/thno.9128
    Keyword
    malaria; hemozoin; laser; vapor nanobubble; theranostics
    Type
    Journal article
    Publisher
    Ivyspring
    Citable link to this page
    https://hdl.handle.net/1911/77426
    Rights
    This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.
    Link to License
    https://creativecommons.org/licenses/by-nc/4.0/
    Metadata
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    • Biochemistry and Cell Biology Publications [118]
    • Faculty Publications [4988]
    • Physics and Astronomy Publications [1771]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map