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dc.contributor.authorDominguez-Medina, Sergio
Blankenburg, Jan
Olson, Jana
Landes, Christy F.
Link, Stephan
dc.date.accessioned 2014-10-06T17:18:02Z
dc.date.available 2014-10-06T17:18:02Z
dc.date.issued 2013
dc.identifier.citation Dominguez-Medina, Sergio, Blankenburg, Jan, Olson, Jana, et al.. "Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions." ACS Sustainable Chemistry & Engineering, 1, no. 7 (2013) American Chemical Society: 833-842. http://dx.doi.org/10.1021/sc400042h.
dc.identifier.urihttps://hdl.handle.net/1911/77401
dc.description.abstract We find that citrate-stabilized gold nanoparticles aggregate and precipitate in saline solutions below the NaCl concentration of many bodily fluids and blood plasma. Our experiments indicate that this is due to complexation of the citrate anions with Na+ cations in solution. A dramatically enhanced colloidal stability is achieved when bovine serum albumin is adsorbed to the gold nanoparticle surface, completely preventing nanoparticle aggregation under harsh environmental conditions where the NaCl concentration is well beyond the isotonic point. Furthermore, we explore the mechanism of the formation of this albumin "corona" and find that monolayer protein adsorption is most likely ruled by hydrophobic interactions. As for many nanotechnology-based biomedical and environmental applications, particle aggregation and sedimentation are undesirable and could substantially increase the risk of toxicological side-effects, the formation of the BSA corona presented here provides a low-cost bio-compatible strategy for nanoparticle stabilization and transport in highly ionic environments.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions
dc.type Journal article
dc.contributor.funder Welch Foundation
dc.contributor.funder Cancer Prevention and Research Institute of Texas
dc.contributor.funder Air Force Office of Scientific Research
dc.contributor.funder National Science Foundation
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle ACS Sustainable Chemistry & Engineering
dc.contributor.org Laboratory for Nanophotonics
dc.subject.keywordgold nanoparticles
surface plasmon
bovine serum albumin
protein corona
correlation spectroscopy
diffusion
dc.citation.volumeNumber 1
dc.citation.issueNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/sc400042h
dc.identifier.pmcid PMC3731158
dc.identifier.pmid 23914342
dc.identifier.grantID C-1664 (Welch Foundation)
dc.identifier.grantID RP110355 (Cancer Prevention and Research Institute of Texas)
dc.identifier.grantID W911NF-12-1-0407 (Air Force Office of Scientific Research)
dc.identifier.grantID C-1787 (Welch Foundation)
dc.identifier.grantID CBET-1134417 (National Science Foundation)
dc.identifier.grantID CHE-1151647 (National Science Foundation)
dc.identifier.grantID GM94246-01A1 (National Institutes of Health)
dc.identifier.grantID NSF (Graduate Research Fellowship 0940902)
dc.type.publication post-print
dc.citation.firstpage 833
dc.citation.lastpage 842


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