Show simple item record

dc.contributor.authorContreras, Elizabeth Q.
Cho, Minjung
Zhu, Huiguang
Puppala, Hema L.
Escalera, Gabriela
Zhong, Weiwei
Colvin, Vicki L.
dc.date.accessioned 2014-10-06T17:17:58Z
dc.date.available 2014-10-06T17:17:58Z
dc.date.issued 2013
dc.identifier.citation Contreras, Elizabeth Q., Cho, Minjung, Zhu, Huiguang, et al.. "Toxicity of Quantum Dots and Cadmium Salt to Caenorhabditis elegans after Multigenerational Exposure." Environmental Science & Technology, 47, no. 2 (2013) American Chemical Society: 1148-1154. http://dx.doi.org/10.1021/es3036785.
dc.identifier.urihttps://hdl.handle.net/1911/77391
dc.description.abstract To fully understand the biological and environmental impacts of nanomaterials requires studies that address both sublethal end points and multigenerational effects. Here, we use a nematode to examine these issues as they relate to exposure to two different types of quantum dots, core (CdSe) and coreヨshell (CdSe/ZnS), and to compare the effect to those observed after cadmium salt exposures. The strong fluorescence of the coreヨshell QDs allowed for the direct visualization of the materials in the digestive track within a few hours of exposure. Multiple end points, including both developmental and locomotive, were examined at QD exposures of low (10 mg/L Cd), medium (50 mg/L Cd), and high concentrations (100 mg/L Cd). While the coreヨshell QDs showed no effect on fitness (lifespan, fertility, growth, and three parameters of motility behavior), the core QDs caused acute effects similar to those found for cadmium salts, suggesting that biological effects may be attributed to cadmium leaching from the more soluble QDs. Over multiple generations, we commonly found that for lower life-cycle exposures to core QDs the parents response was generally a poor predictor of the effects on progeny. At the highest concentrations, however, biological effects found for the first generation were commonly similar in magnitude to those found in future generations.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Toxicity of Quantum Dots and Cadmium Salt to Caenorhabditis elegans after Multigenerational Exposure
dc.type Journal article
dc.contributor.funder National Science Foundation
dc.contributor.funder U.S. Environmental Protection Agency
dc.contributor.funder National Institutes of Health
dc.contributor.funder Kinship Foundation
dc.citation.journalTitle Environmental Science & Technology
dc.subject.keywordCaenorhabditis elegans
quantum dots
multigenerational
toxicity
Cadmium
dc.citation.volumeNumber 47
dc.citation.issueNumber 2
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/es3036785
dc.identifier.pmcid PMC3556816
dc.identifier.pmid 23241207
dc.identifier.grantID EEC 0647452 (National Science Foundation)
dc.identifier.grantID RD834557501-0 (U.S. Environmental Protection Agency)
dc.identifier.grantID R00HG004724 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 1148
dc.citation.lastpage 1154


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record