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dc.contributor.authorLiu, Lu
Sun, Meiqing
Li, Qingzhao
Zhang, Hongmei
Alvarez, Pedro J.J.
Liu, Huajie
Chen, Wei
dc.date.accessioned 2014-07-23T15:30:35Z
dc.date.available 2014-07-23T15:30:35Z
dc.date.issued 2014
dc.identifier.citation Liu, Lu, Sun, Meiqing, Li, Qingzhao, et al.. "Genotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodots." Environmental Engineering Science, 31, no. 7 (2014) Mary Ann Liebert, Inc.: 373-380. http://dx.doi.org/10.1089/ees.2013.0417.
dc.identifier.urihttps://hdl.handle.net/1911/76257
dc.description.abstract Cadmium sulfide (CdS) nanomaterials (such as CdS nanodots or nanorods) are widely used in optical, electronic, and biological applications. Large-scale production and use of these materials will likely result in accidental and incidental releases, which raise concerns about their potential environmental and human-health impacts. Most studies on toxicity of Cd-containing nanomaterials have focused on nanodots, and the relative toxicity of Cd containing nanorods is not well understood. Here, we compared genotoxicity and cytotoxicity of CdS nanorods (30-50nm diameter, 500-1100 nm length) and cubic CdS nanodots (3-5 nm) in mice by examining total cadmium accumulation in organs, acute toxicity, DNA damage, spermatozoon viability and abnormality, kidney and liver damage, and oxidative stress. Compared with (smaller) nanodots, nanorods resulted in relatively low bioaccumulation, acute toxicity, and damage to spermatozoa and the tested organs. Differences in toxicity between CdS nanodots and nanorods could not be fully explained by differences in their metal ion (Cd2 + ) release patterns, based on control tests with mice gavaged with dissolved CdCl2 at equivalent concentrations. This underscores that toxicity of metallic nanomaterials could not be solely predicted based either on their elemental composition or on the amount of ions released before receptor intake. Particle morphology (including size) may also need to be considered.
dc.language.iso eng
dc.publisher Mary Ann Liebert, Inc.
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Genotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodots
dc.type Journal article
dc.citation.journalTitle Environmental Engineering Science
dc.subject.keywordcadmium sulfide
cytotoxicity
genotoxicity
nanodots
nanorods
dc.citation.volumeNumber 31
dc.citation.issueNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1089/ees.2013.0417
dc.identifier.pmid 25053877
dc.type.publication publisher version
dc.citation.firstpage 373
dc.citation.lastpage 380


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