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dc.contributor.authorNicolaou, K.C.
Hale, Christopher R.H.
dc.date.accessioned 2014-04-08T13:51:07Z
dc.date.available 2014-04-08T13:51:07Z
dc.date.issued 2014
dc.identifier.citation Nicolaou, K.C. and Hale, Christopher R.H.. "The endeavor of total synthesis and its impact on chemistry, biology and medicine." National Science Review, (2014) Oxford University Press: http://dx.doi.org/10.1093/nsr/nwu001.
dc.identifier.urihttps://hdl.handle.net/1911/75842
dc.description.abstract The synthesis of urea in 1828 set in motion the discipline of organic synthesis in general and of total synthesis in particular, the art and science of synthesizing natural products, the molecules of living nature. Early endeavors in total synthesis had as their main objective the proof of structure of the target molecule. Later on, the primary goal became the demonstration of the power of synthesis to construct complex molecules through appropriately devised strategies, making the endeavor an achievement whose value was measured by its elegance and efficiency. While these objectives continue to be important, contemporary endeavors in total synthesis are increasingly focused on practical aspects, including method development, efficiency, and biological and medical relevance. In this article, the emergence and evolution of total synthesis to its present state is traced, selected total syntheses from the author's laboratories are highlighted, and projections for the future of the field are discussed.
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title The endeavor of total synthesis and its impact on chemistry, biology and medicine
dc.type Journal article
dc.citation.journalTitle National Science Review
dc.contributor.org BioScience Research Collaborative
dc.subject.keywordorganic synthesis
natural products
chemistry
biology
medicine
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1093/nsr/nwu001
dc.type.publication publisher version


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