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dc.contributor.authorSpicer, Patrick P.
Shah, Sarita R.
Henslee, Allan M.
Watson, Brendan M.
Kinard, Lucas A.
Kretlow, James D.
Bevil, Kristin
Kattchee, Lauren
Bennett, George N.
Demian, Nagi
Mende, Katrin
Murray, Clinton K.
Jansen, John A.
Wong, Mark E.
Mikos, Antonios G.
Kasper, F. Kurtis
dc.date.accessioned 2014-03-12T21:47:26Z
dc.date.available 2014-03-12T21:47:26Z
dc.date.issued 2013-11
dc.identifier.citation Spicer, Patrick P., Shah, Sarita R., Henslee, Allan M., et al.. "Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model." Acta Biomaterialia, 9, no. 11 (2013) Elsevier: 8832-8839. http://dx.doi.org/10.1016/j.actbio.2013.07.018.
dc.identifier.urihttps://hdl.handle.net/1911/75577
dc.description.abstract This study evaluated the in vitro and in vivo performance of antibiotic-releasing porous polymethylmethacrylate (PMMA)-based space maintainers comprising a gelatin hydrogel porogen and a poly(DL-lactic-co-glycolic acid) (PLGA) particulate carrier for antibiotic delivery. Colistin was released in vitro from either gelatin or PLGA microparticle loaded PMMA constructs, with gelatin-loaded constructs releasing colistin over approximately 7 days and PLGA microparticle-loaded constructs releasing colistin up to 8 weeks. Three formulations with either a burst release or extended release in different doses were tested in a rabbit mandibular defect inoculated with Acinetobacter baumannii (2 × 107 colony forming units/mL). In addition, one material control that released antibiotic but was not inoculated with A. baumannii was tested. A. baumannii was not detectable in any animal after 12 weeks by culture of the defect, saliva, or blood. Defects with high-dose, extended-release implants had greater soft tissue healing compared to defects with burst release implants, with 8 out of 10 animals showing healed mucosae compared to 2 out of 10 with healed mucosae, respectively. Extended release of locally delivered colistin via a PLGA microparticle carrier improved soft tissue healing over the implants compared to burst release of colistin from a gelatin carrier.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model
dc.type Journal article
dc.contributor.funder Armed Forces Institute of Regenerative Medicine
dc.contributor.funder Robert and Janice McNair Foundation
dc.citation.journalTitle Acta Biomaterialia
dc.subject.keywordspace maintainer
craniofacial reconstruction
antibiotic delivery
infected defect
composite tissue defect
dc.citation.volumeNumber 9
dc.citation.issueNumber 11
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2013.07.018
dc.identifier.pmid 23891810
dc.identifier.grantID W81XWH-08-2-0032 (Armed Forces Institute of Regenerative Medicine)
dc.type.publication post-print
dc.citation.firstpage 8832
dc.citation.lastpage 8839


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