Now showing items 1-10 of 17
Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart
(American Chemical Society, 2014)
The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled ...
A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland
Objectives/Hypothesis: To create a novel model for development of a tissue-engineered salivary gland from human salivary gland cells that retains progenitor cell markers useful for treatment of radiation-induced xerostomia. Study Design: A three-dimensional (3D) hyaluronic acid (HA)-based hydrogel scaffold was used to encapsulate primary human salivary ...
Novel applications of statins for bone regeneration
(Oxford University Press, 2015)
The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Because the mevalonate pathway is responsible for the synthesis of a wide variety of important ...
In vitroﾠandﾠin vivoﾠevaluation of self-mineralization and biocompatibility of injectable, dual-gelling hydrogels for bone tissue engineering
In this study, we investigated the mineralization capacity and biocompatibility of injectable, dual-gelling hydrogels in a rat cranial defect as a function of hydrogel hydrophobicity from either the copolymerization of a hydrolyzable lactone ring or the hydrogel polymer content. The hydrogel system comprised a poly(N-isopropylacrylamide)-based ...
Application of Hydrogels in Heart Valve Tissue Engineering
(Begell House, 2015)
With an increasing number of patients requiring valve replacements, there is heightened interest in advancing heart valve tissue engineering (HVTE) to provide solutions to the many limitations of current surgical treatments. A variety of materials have been developed as scaffolds for HVTE including natural polymers, synthetic polymers, and decellularized ...
Scaffolds to Control Inflammation and Facilitate Dental Pulp Regeneration
In dentistry, the maintenance of a vital dental pulp is of paramount importance because teeth devitalized by root canal treatment may become more brittle and prone to structural failure over time. Advanced carious lesions can irreversibly damage the dental pulp by propagating a sustained inflammatory response throughout the tissue. Although the ...
Tissue engineering perfusable cancer models
The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell ...
Synthesis, Physicochemical Characterization, and Cytocompatibility of Bioresorbable, Dual-Gelling Injectable Hydrogels
(American Chemical Society, 2014)
Injectable, dual-gelling hydrogels were successfully developed through the combination of physical thermogellation at 37 °C and favorable amine:epoxy chemical cross-linking. Poly(N-isopropylacrylamide)-based thermogelling macromers with a hydrolyzable lactone ring and epoxy pendant groups and a biodegradable diamine-functionalized polyamidoamine ...
Leveraging synthetic biology for tissue engineering applications
(The Japanese Society of Inflammation and Regeneration, 2014)
Restoration of damaged tissues and organs requires precise control of cellular processes at the molecular level. Synthetic biology offers genetic tools that can be used to program the molecular biology of the cell, thereby potentially overcoming the various challenges hampering contemporary tissue engineering applications.