Now showing items 4536-4555 of 5065

    • T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients 

      Tong, Yin; Li, Zhoufang; Zhang, Hua; Xia, Ligang; Zhang, Meng; (2016)
      Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors (TCRs), we used a high-throughput immune repertoire sequencing technique to profile the spectrum of TCRs in individual ...
    • Tailoring the Attraction of Polymers toward Surfaces 

      Stein, Gila E.; Laws, Travis S.; Verduzco, Rafael (2019)
      In polymer blends and block copolymers, one constituent (or segment type) is often enriched at the surface. This enrichment has important consequences for a variety of surface functions, including wettability, adhesive interactions, and fouling resistance, and can also influence the structure that forms deeper into the bulk. Herein, we review the ...
    • Tales from the crypt: a parasitoid manipulates the behaviour of its parasite host 

      Weinersmith, Kelly L.; Liu, Sean M.; Forbes, Andrew A.; Egan, Scott P. (2017)
      There are many examples of apparent manipulation of host phenotype by parasites, yet few examples of hypermanipulation—where a phenotype-manipulating parasite is itself manipulated by a parasite. Moreover, few studies confirm manipulation is occurring by quantifying whether the host's changed phenotype increases parasite fitness. Here we describe a ...
    • Tamim al-Dari 

      Cook, David (1998)
    • Tannic Acid as a Small-Molecule Binder for Silicon Anodes 

      Sarang, Kasturi T.; Li, Xiaoyi; Miranda, Andrea; Terlier, Tanguy; Oh, Eun-Suok; (2020)
      Increasing demand for portable electronic devices, electric vehicles, and grid scale energy storage has spurred interest in developing high-capacity rechargeable lithium-ion batteries (LIBs). Silicon is an abundantly available anode material that has a theoretical gravimetric capacity of 3579 mAh/g and a low operating potential of 0–1 V vs Li/Li+. ...
    • Target highlights in CASP13: Experimental target structures through the eyes of their authors 

      Lepore, Rosalba; Kryshtafovych, Andriy; Alahuhta, Markus; Veraszto, Harshul A.; Bomble, Yannick J.; (2019)
      The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.
    • Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy 

      Tan, Zheqiong; Xiao, Lanbo; Tang, Min; Bai, Fang; Li, Jiangjiang; (2018)
      Nasopharyngeal carcinoma (NPC) has a particularly high prevalence in southern China, southeastern Asia and northern Africa. Radiation resistance remains a serious obstacle to successful treatment in NPC. This study aimed to explore the metabolic feature of radiation-resistant NPC cells and identify new molecular-targeted agents to improve the therapeutic ...
    • Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells 

      Chen, Wenxue; Ayala-Orozco, Ciceron; Biswal, Nrusingh C.; Perez-Torres, Carlos; Bartels, Marc; (2014)
      Aim: We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. Materials & methods: Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in ...
    • Targeting the Apoa1 locus for liver-directed gene therapy 

      De Giorgi, Marco; Li, Ang; Hurley, Ayrea; Barzi, Mercedes; Doerfler, Alexandria M.; (2021)
      Clinical application of somatic genome editing requires therapeutics that are generalizable to a broad range of patients. Targeted insertion of promoterless transgenes can ensure that edits are permanent and broadly applicable while minimizing risks of off-target integration. In the liver, the Albumin (Alb) locus is currently the only well-characterized ...
    • Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity 

      Mandal, Pijus K.; Morlacchi, Pietro; Knight, J. Morgan; Link, Todd M.; Lee, Gilbert R. IV; (2015)
      Signal transducer and activator of transcription 6 (STAT6) transmits signals from cytokines IL-4 and IL-13 and is activated in allergic airway disease. We are developing phosphopeptide mimetics targeting the SH2 domain of STAT6 to block recruitment to phosphotyrosine residues on IL-4 or IL-13 receptors and subsequent Tyr641 phosphorylation to inhibit ...
    • Teacher Quality in Public and Private Schools under a Voucher System: The Case of Chile 

      Behrman, Jere R.; Tincani, Michela M.; Todd, Petra E.; Wolpin, Kenneth I. (2016)
      Chile is unusual in having long-term experience with nationwide school vouchers. A key criticism of school voucher systems is that they make it easier for private schools to attract better teachers to the detriment of public schools. This paper uses longitudinal data from Chile to estimate a discrete choice dynamic programming (DCDP) model of teacher ...
    • Teaching the Biological Consequences of Alcohol Abuse through an Online Game: Impacts among Secondary Students 

      (2012)
      A multimedia game was designed to serve as a dual-purpose intervention that aligned with National Science Content Standards, while also conveying knowledge about the consequences of alcohol consumption for a secondary school audience. A tertiary goal was to positively impact adolescents' attitudes toward science through career role-play experiences ...
    • Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS) to Improve Collaboration in School Mental Health: Protocol for a Mixed Methods Hybrid Effectiveness-Implementation Study 

      Kuriyan, Aparajita; Kinkler, Grace; Cidav, Zuleyha; Kang-Yi, Christina; Eiraldi, Ricardo; (2021)
      Background: Public schools in the United States are the main providers of mental health services to children but are often ill equipped to provide quality mental health care, especially in low-income urban communities. Schools often rely on partnerships with community organizations to provide mental health services to students. However, collaboration ...
    • Teammate familiarity and risk of injury in emergency medical services 

      Patterson, P. Daniel; Weaver, Matthew D.; Landsittel, Douglas P.; Krackhardt, David; Hostler, David; (2016)
      Objective: We investigated the association between teammate familiarity and workplace injury in the emergency medical services (EMS) setting. Methods: From January 2011 to November 2013, we abstracted a mean of 29 months of shift records and Occupational Safety Health Administration injury logs from 14 EMS organisations with 37 total bases located ...
    • A Technique to Increase Accessibility to Late-Stage Chick Embryos for In Ovo Manipulations 

      (2013)
      Background: During early development, avian embryos are easily accessible in ovo for transplantations and experimental perturbations. However, these qualities of the avian embryonic model rapidly wane shortly after embryonic day (E)4 when the embryo is obscured by extraembryonic membranes, making it difficult to study developmental events that occur ...
    • Temperature and polarization dependence of low-energy magnetic fluctuations in nearly optimally doped NaFe0.9785Co0.0215As 

      Song, Yu; Wang, Weiyi; Zhang, Chenglin; Gu, Yanhong; Lu, Xingye; (2017)
      We use unpolarized and polarized neutron scattering to study the temperature and polarization dependence of low-energy magnetic fluctuations in nearly optimally doped NaFe0.9785Co0.0215As, with coexisting superconductivity (Tc≈19 K) and weak antiferromagnetic order (TN≈30 K, ordered moment ≈0.02μB/Fe). A single spin resonance mode with intensity ...
    • Temperature dependence on the mass susceptibility and mass magnetization of superparamagnetic Mn–Zn–ferrite nanoparticles as contrast agents for magnetic imaging of oil and gas reservoirs 

      Morrow, Lauren; Snow, Brendan; Ali, Arfan; Maguire-Boyle, Samuel J.; Almutairi, Zeyad; (2018)
      The mass susceptibility (χmass) and mass magnetization (Mmass) were determined for a series of ternary manganese and zinc ferrite nanoparticles (Mn–Zn ferrite NPs, MnxZn1−xFe2O4) with different Mn:Zn ratios (0.08 ≤ x ≤ 4.67), prepared by the thermal decomposition reaction of the appropriate metal acetylacetonate complexes, and for the binary homologs ...
    • Temperature-dependent optical properties of titanium nitride 

      Briggs, Justin A.; Naik, Gururaj V.; Zhao, Yang; Petach, Trevor A.; Sahasrabuddhe, Kunal; (2017)
      The refractory metal titanium nitride is promising for high-temperature nanophotonic and plasmonic applications, but its optical properties have not been studied at temperatures exceeding 400 °C. Here, we perform in-situ high-temperature ellipsometry to quantify the permittivity of TiN films from room temperature to 1258 °C. We find that the material ...
    • Template–Framework Interactions in Tetraethylammonium-Directed Zeolite Synthesis 

      Schmidt, Joel E.; Fu, Donglong; Deem, Michael W.; Weckhuysen, Bert M. (2016)
      Zeolites, having widespread applications in chemical industries, are often synthesized using organic templates. These can be cost-prohibitive, motivating investigations into their role in promoting crystallization. Herein, the relationship between framework structure, chemical composition, synthesis conditions and the conformation of the occluded, ...
    • Temporal and spectral characteristics of dynamic functional connectivity between resting-state networks reveal information beyond static connectivity 

      Chiang, Sharon; Vankov, Emilian R.; Yeh, Hsiang J.; Guindani, Michele; Vannucci, Marina; (2018)
      Estimation of functional connectivity (FC) has become an increasingly powerful tool for investigating healthy and abnormal brain function. Static connectivity, in particular, has played a large part in guiding conclusions from the majority of resting-state functional MRI studies. However, accumulating evidence points to the presence of temporal ...