Now showing items 3393-3412 of 5032

    • q-Blossoming for analytic functions 

      Goldman, Ron; Simeonov, Plamen (2018)
      We construct aᅠq-analog of the blossom for analytic functions, the analyticᅠq-blossom. Thisᅠq-analog also extends the notion ofᅠq-blossoming from polynomials to analytic functions. We then apply this analyticᅠq-blossom to derive identities for analytic functions represented in terms of theᅠq-Poisson basis, includingᅠq-versions of the Marsden identity ...
    • Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice 

      Huang, Kun; Zhang, Yufei; Hui, Xianfeng; Zhao, Ya; Gong, Wenxiao; (2021)
      Background: An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2) pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection and recapitulate lung disease like those seen in humans. The angiotensin-converting enzyme 2 (ACE2) is a functional receptor for SARS-CoV-2, but mice are resistant to the infection because ...
    • Quantification of HIV-1 DNA using Real-Time Recombinase Polymerase Amplification 

      (2014)
      Although recombinase polymerase amplification (RPA) has many advantages for the detection of pathogenic nucleic acids in point-of-care applications, RPA has not yet been applied for has not yet been implemented to quantify sample concentration using a standard curve. Here we describe a real-time RPA assay with an internal positive control and an ...
    • Quantification of Lifeline System Interdependencies after the 27 February 2010 Mw 8.8 Offshore Maule, Chile, Earthquake 

      (2012-06)
      Data on lifeline system service restoration is seldom exploited for the calibration of performance prediction models or for response comparisons across systems and events. This study explores utility restoration curves after the 2010 Chilean earthquake through a time series method to quantify coupling strengths across lifeline systems. When consistent ...
    • Quantification of Myxococcus xanthus Aggregation and Rippling Behaviors: Deep-Learning Transformation of Phase-Contrast into Fluorescence Microscopy Images 

      Zhang, Jiangguo; Comstock, Jessica A.; Cotter, Christopher R.; Murphy, Patrick A.; Nie, Weili; (2021)
      Myxococcus xanthus bacteria are a model system for understanding pattern formation and collective cell behaviors. When starving, cells aggregate into fruiting bodies to form metabolically inert spores. During predation, cells self-organize into traveling cell-density waves termed ripples. Both phase-contrast and fluorescence microscopy are used to ...
    • Quantifying cell transitions in C. elegans with data-fitted landscape models 

      Camacho-Aguilar, Elena; Warmflash, Aryeh; Rand, David A. (2021)
      Increasing interest has emerged in new mathematical approaches that simplify the study of complex differentiation processes by formalizing Waddington’s landscape metaphor. However, a rational method to build these landscape models remains an open problem. Here we study vulval development in C. elegans by developing a framework based on Catastrophe ...
    • Quantifying cognitive resilience in Alzheimer’s Disease: The Alzheimer’s Disease Cognitive Resilience Score 

      Yao, Tianyi; Sweeney, Elizabeth; Nagorski, John; Shulman, Joshua M.; Allen, Genevera I. (2020)
      Even though there is a clear link between Alzheimer’s Disease (AD) related neuropathology and cognitive decline, numerous studies have observed that healthy cognition can exist in the presence of extensive AD pathology, a phenomenon sometimes called Cognitive Resilience (CR). To better understand and study CR, we develop the Alzheimer’s Disease ...
    • Quantifying pulmonary perfusion from noncontrast computed tomography 

      Castillo, Edward; Nair, Girish; Turner‐Lawrence, Danielle; Myziuk, Nicholas; Emerson, Scott; (2021)
      Purpose: Computed tomography (CT)-derived ventilation methods compute respiratory induced volume changes as a surrogate for pulmonary ventilation. Currently, there are no known methods to derive perfusion information from noncontrast CT. We introduce a novel CT-Perfusion (CT-P) method for computing the magnitude mass changes apparent on dynamic ...
    • Quantifying spectral changes experienced by plasmonic nanoparticles in a cellular environment to inform biomedical nanoparticle design 

      (2014)
      Metal nanoparticles (NPs) scatter and absorb light in precise, designable ways, making them agile candidates for a variety of biomedical applications. When NPs are introduced to a physiological environment and interact with cells, their physicochemical properties can change as proteins adsorb on their surface and they agglomerate within intracellular ...
    • Quantitative analysis of gas phase molecular constituents using frequency-modulated rotational spectroscopy 

      Lou, Minghe; Swearer, Dayne F.; Gottheim, Samuel; Phillips, Dane J.; Simmons, Jay G. Jr.; (2019)
      Rotational spectroscopy has been used for decades for virtually unambiguous identification of gas phase molecular species, but it has rarely been used for the quantitative analysis of molecular concentrations. Challenges have included the nontrivial reconstruction of integrated line strengths from modulated spectra, the correlation of pressure-dependent ...
    • Quantitative analysis of gas phase molecular constituents using frequency-modulated rotational spectroscopy 

      Lou, Minghe; Swearer, Dayne F.; Gottheim, Samuel; Phillips, Dane J.; Simmons, Jay G.; (2019)
      Rotational spectroscopy has been used for decades for virtually unambiguous identification of gas phase molecular species, but it has rarely been used for the quantitative analysis of molecular concentrations. Challenges have included the nontrivial reconstruction of integrated line strengths from modulated spectra, the correlation of pressure-dependent ...
    • Quantitative Analysis of High-Resolution Microendoscopic Images for Diagnosis of Esophageal Squamous Cell Carcinomaᅠ 

      Shin, Dongsuk; Protano, Marion-Anna; Polydorides, Alexandros D.; Dawsey, Sanford M.; Pierce, Mark C.; (2015)
      Background & Aims: High-resolution microendoscopy is an optical imaging technique with the potential to improve the accuracy of endoscopic screening for esophageal squamous neoplasia. Although these microscopic images can be interpreted readily by trained personnel, quantitative image analysis software could facilitate the use of this technology in ...
    • Quantitative analysis of high-resolution microendoscopic images for diagnosis of neoplasia in patients with Barrett’s esophagus 

      (2016)
      Background and Aims: Previous studies show that microendoscopic images can be interpreted visually to identify the presence of neoplasia in patients with Barrett’s esophagus (BE), but this approach is subjective and requires clinical expertise. This study describes an approach for quantitative image analysis of microendoscopic images to identify ...
    • Quantitative Analysis of α-Synuclein Solubility in Living Cells Using Split GFP Complementation 

      Kothawala, Ahmed; Kilpatrick, Kiri; Novoa, Jose Andres; Segatori, Laura (2012)
      Presently incurable, Parkinson's disease (PD) is the most common neurodegenerative movement disorder and affects 1% of the population over 60 years of age. The hallmarks of PD pathogenesis are the loss of dopaminergic neurons in the substantia nigra pars compacta, and the occurrence of proteinaceous cytoplasmic inclusions (Lewy bodies) in surviving ...
    • Quantitative analysis of in vivo high-resolution microendoscopic images for the detection of neoplastic colorectal polyps 

      Tang, Yubo; Polydorides, Alexandros D.; Anandasabapathy, Sharmila; Richards-Kortum, Rebecca R. (2018)
      Colonoscopy is routinely performed for colorectal cancer screening but lacks the capability to accurately characterize precursor lesions and early cancers. High-resolution microendoscopy (HRME) is a low-cost imaging tool to visualize colorectal polyps with subcellular resolution. We present a computer-aided algorithm to evaluate HRME images of ...
    • Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level 

      Kardyńska, Maøgorzata; Paszek, Anna; Śmieja, Jarosøaw; Spiller, David; Widøak, Wiesøawa; (2018)
      Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However, specific mechanisms linking the HS response pathways to major cellular signaling systems are not fully understood. Here we used integrated computational and experimental approaches to quantitatively ...
    • Quantitative comparison of adaptive sampling methods for protein dynamics 

      Hruska, Eugen; Abella, Jayvee R.; Nüske, Feliks; Kavraki, Lydia E.; Clementi, Cecilia; (2018)
      Adaptive sampling methods, often used in combination with Markov state models, are becoming increasingly popular for speeding up rare events in simulation such as molecular dynamics (MD) without biasing the system dynamics. Several adaptive sampling strategies have been proposed, but it is not clear which methods perform better for different physical ...
    • Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia 

      (2015)
      Current imaging tools are associated with inconsistent sensitivity and specificity for detection of Barrett’s-associated neoplasia. Optical imaging has shown promise in improving the classification of neoplasia in vivo. The goal of this pilot study was to evaluate whether in vivo vital dye fluorescence imaging (VFI) has the potential to improve the ...
    • Quantitative evaluation of performance of three-dimensional printed lenses 

      Gawedzinski, John; Pawlowski, Michal E.; Tkaczyk, Tomasz S. (2017)
      We present an analysis of the shape, surface quality, and imaging capabilities of custom three-dimensional (3-D) printed lenses. 3-D printing technology enables lens prototypes to be fabricated without restrictions on surface geometry. Thus, spherical, aspherical, and rotationally nonsymmetric lenses can be manufactured in an integrated production ...
    • Quantitative Testing of fMRI-Compatibility of an Electrically Active Mechatronic Device for Robot-Assisted Sensorimotor Protocols 

      Farrens, Andria J.; Zonnino, Andrea; Erwin, Andrew; O'Malley, Marcia K.; Johnson, Curtis L.; (2018)
      OBJECTIVE: To develop a quantitative set of methods for testing the functional magnetic resonance imaging (fMRI) compatibility of an electrically-active mechatronic device developed to support sensorimotor protocols during fMRI. METHODS: The set of methods includes phantom and in vivo experiments to measure the effect of a progressively broader set ...