Now showing items 1605-1624 of 5032

    • Gadonanotube materials as new intracellular MRI contrast agents for stem cell labeling 

      Hernández-Rivera, Mayra; Wilson, Lon J. (2016)
      Stem cells possess great potential for different medical applications and every year more investigators join this field of study. As interest in stem cells has increased, it has become essential to track the cellsin vivo in order to study their biodistribution and possible tissue accumulation. Here, we review the use of two new carbon nanotube-based ...
    • A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility 

      (2012)
      Auxin regulates many aspects of plant development, in part, through degradation of the Aux/IAA family of transcriptional repressors. Consequently, stabilizing mutations in several Aux/IAA proteins confer reduced auxin responsiveness. However, of the 29 apparent Aux/IAA proteins in Arabidopsis thaliana, fewer than half have roles established through ...
    • Gapless topological Fulde-Ferrell superfluidity induced by an in-plane Zeeman field 

      Hu, Hui; Dong, Lin; Cao, Ye; Pu, Han; Liu, Xia-Ji (2014)
      Topological superfluids are recently discovered quantum matter that hosts topologically protected gapless edge states known as Majorana fermions—exotic quantum particles that act as their own antiparticles and obey non-Abelian statistics. Their realizations are believed to lie at the heart of future technologies such as fault-tolerant quantum ...
    • Gas density drops inside dust cavities of transitional disks around young stars observed with ALMA 

      van der Marel, N.; van Dishoeck, E.F.; Bruderer, S.; Pérez, L.; Isella, A. (2015)
      Context. Transitional disks with large dust cavities are important laboratories in which to study planet formation and disk evolution. Cold gas may still be present inside these cavities, but quantying this gas is challenging. The gas content is important for constraining the origin of the dust cavity. Aims. We use Atacama Large Millimeter/submillimeter ...
    • Gas hydrate dissociation prolongs acidification of the Anthropocene oceans 

      Boudreau, Bernard P.; Luo, Yiming; Meysman, Filip J.R.; Middelburg, Jack J.; Dickens, Gerald R. (2015)
      Anthropogenic warming of the oceans can release methane (CH4) currently stored in sediments as gas hydrates. This CH4 will be oxidized to CO2, thus increasing the acidification of the oceans. We employ a biogeochemical model of the multimillennial carbon cycle to determine the evolution of the oceanic dissolved carbonate system over the next 13 kyr ...
    • Gelatin carriers for drug and cell delivery in tissue engineering 

      (2014)
      The ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation ...
    • Gender and Colonial Politics after the Versailles Treaty 

      Wildenthal, Lora; Canning, Kathleen; Barndt, Kerstin; McGuire, Kristin (2010)
    • Gender Difference or Parallel Publics? The Dynamics of Defense Spending Opinions in the United States, 1965-2007 

      Eichenberg, Richard C.; Stoll, Richard J. (2012)
      Gender is now recognized as an important dividing line in American political life, and scholars have accumulated evidence that national security issues are an important reason for gender differences in policy preferences. We therefore expect that the dynamics of support for defense spending among men and women will differ. In contrast, several ...
    • Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples 

      Gorlov, Ivan P; Pikielny, Claudio W; Frost, Hildreth R; Her, Stephanie C; Cole, Michael D; (2018-11-19)
      Abstract Background Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations. However, mutation frequency alone is insufficient to identify cancer genes because mutability is ...
    • Gene correction for SCID-X1 in long-term hematopoietic stem cells 

      Pavel-Dinu, Mara; Wiebking, Volker; Dejene, Beruh T.; Srifa, Waracharee; Mantri, Sruthi; (2019)
      Gene correction in human long-term hematopoietic stem cells (LT-HSCs) could be an effective therapy for monogenic diseases of the blood and immune system. Here we describe an approach for X-linked sSevere cCombined iImmunodeficiency (SCID-X1) using targeted integration of a cDNA into the endogenous start codon to functionally correct disease-causing ...
    • Gene Duplicability-Connectivity-Complexity across Organisms and a Neutral Evolutionary Explanation 

      (2012)
      Gene duplication has long been acknowledged by biologists as a major evolutionary force shaping genomic architectures and characteristics across the Tree of Life. Major research has been conducting on elucidating the fate of duplicated genes in a variety of organisms, as well as factors that affect a geneメs duplicabilityヨthat is, the tendency of ...
    • Gene Expression of Endangered Coral (Orbicella spp.) in Flower Garden Banks National Marine Sanctuary After Hurricane Harvey 

      Wright, Rachel M.; Correa, Adrienne M.S.; Quigley, Lucinda A.; Santiago-Vázquez, Lory Z.; Shamberger, Kathryn E.F.; (2019)
      About 190 km south of the Texas–Louisiana border, the East and West Flower Garden Banks (FGB) have maintained > 50% coral cover with infrequent and minor incidents of disease or bleaching since monitoring began in the 1970s. However, a mortality event, affecting 5.6 ha (2.6% of the area) of the East FGB, occurred in late July 2016 and coincided with ...
    • Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum 

      Chakraborty, Priyanka; George, Jason T; Woodward, Wendy A; Levine, Herbert; Jolly, Mohit Kumar; (2021)
      Inflammatory breast cancer (IBC) is a highly aggressive breast cancer that metastasizes largely via tumor emboli, and has a 5-year survival rate of less than 30%. No unique genomic signature has yet been identified for IBC nor has any specific molecular therapeutic been developed to manage the disease. Thus, identifying gene expression signatures ...
    • General neural network approach to compressive feature extraction 

      Giljum, Anthony; Giljum, Anthony; Liu, Weidi; Liu, Weidi; Li, Le; (2021)
      Computer vision with a single-pixel camera is currently limited by a trade-off between reconstruction capability and image classification accuracy. If random projections are used to sample the scene, then reconstruction is possible but classification accuracy suffers, especially in cases with significant background signal. If data-driven projections ...
    • General Prediction of Peptide-MHC Binding Modes Using Incremental Docking: A Proof of Concept 

      Antunes, Dinler A.; Devaurs, Didier; Moll, Mark; Lizée, Gregory; Kavraki, Lydia E. (2018)
      The class I major histocompatibility complex (MHC) is capable of binding peptides derived from intracellular proteins and displaying them at the cell surface. The recognition of these peptide-MHC (pMHC) complexes by T-cells is the cornerstone of cellular immunity, enabling the elimination of infected or tumoral cells. T-cell-based immunotherapies ...
    • Generalized Manning Condensation Model Captures the RNA Ion Atmosphere 

      Hayes, Ryan L.; Noel, Jeffrey K.; Mandic, Ana; Whitford, Paul C.; Sanbonmatsu, Karissa Y.; (2015)
      RNA is highly sensitive to the ionic environment and typically requires Mg2+ to form compact structures. There is a need for models capable of describing the ion atmosphere surrounding RNA with quantitative accuracy. We present a model of RNA electrostatics and apply it within coarse-grained molecular dynamics simulation. The model treats Mg2+ ions ...
    • Generalized method to design phase masks for 3D super-resolution microscopy 

      Wang, Wenxiao; Ye, Fan; Shen, Hao; Moringo, Nicholas A.; Dutta, Chayan; (2019)
      Point spread function (PSF) engineering by phase modulation is a novel approach to three-dimensional (3D) super-resolution microscopy, with different point spread functions being proposed for specific applications. It is often not easy to achieve the desired shape of engineered point spread functions because it is challenging to determine the correct ...
    • Generalized recovery algorithm for 3D super-resolution microscopy using rotating point spread functions 

      Shuang, Bo; Wang, Wenxiao; Shen, Hao; Tauzin, Lawrence J.; Flatebo, Charlotte; (2016)
      Super-resolution microscopy with phase masks is a promising technique for 3D imaging and tracking. Due to the complexity of the resultant point spread functions, generalized recovery algorithms are still missing. We introduce a 3D super-resolution recovery algorithm that works for a variety of phase masks generating 3D point spread functions. A fast ...