Now showing items 1-20 of 15373

    • Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties 

      Hempel, Tim; Elez, Katarina; Krüger, Nadine; Raich, Lluís; Shrimp, Jonathan H. ; (2021)
      SARS-CoV-2, the cause of the COVID-19 pandemic, exploits host cell proteins for viral entry into human lung cells. One of them, the protease TMPRSS2, is required to activate the viral spike protein (S). Even though two inhibitors, camostat and nafamostat, are known to inhibit TMPRSS2 and block cell entry of SARS-CoV-2, finding further potent therapeutic ...
    • Teaching with Quantitative Data in Undergraduate Social Science Classes at Rice University: An Ithaka S+R Local Report 

      Spiro, Lisa; Rimmer, Miaomiao; Goetz, Joseph E.; Thomas, Amanda L. (2021-10)
    • Single-cell stochastic modelling of the action of antimicrobial peptides on bacteria 

      Teimouri,Hamid; Nguyen, Thao N.; Kolomeisky, Anatoly B.; Center for Theoretical Biological Physics (2021)
      Antimicrobial peptides (AMPs) produced by multi-cellular organisms as their immune system's defence against microbes are actively considered as natural alternatives to conventional antibiotics. Although substantial progress has been achieved in studying the AMPs, the microscopic mechanisms of their functioning remain not well understood. Here, we ...
    • Urban mining by flash Joule heating 

      Deng, Bing; Luong, Duy Xuan; Wang, Zhe; Kittrell, Carter; McHugh, Emily A.; (2021)
      Precious metal recovery from electronic waste, termed urban mining, is important for a circular economy. Present methods for urban mining, mainly smelting and leaching, suffer from lengthy purification processes and negative environmental impacts. Here, a solvent-free and sustainable process by flash Joule heating is disclosed to recover precious ...
    • Triple reassortment increases compatibility among viral ribonucleoprotein genes of contemporary avian and human influenza A viruses 

      Waters, Kaitlyn; Gao, Cheng; Ykema, Matthew; Han, Lei; Voth, Lynden; (2021)
      Compatibility among the influenza A virus (IAV) ribonucleoprotein (RNP) genes affects viral replication efficiency and can limit the emergence of novel reassortants, including those with potential pandemic risks. In this study, we determined the polymerase activities of 2,451 RNP reassortants among three seasonal and eight enzootic IAVs by using a ...
    • Near-infrared laser photoacoustic gas sensor for simultaneous detection of CO and H2S 

      Yin, Xukun; Yin, Xukun; Gao, Miao; Miao, Ruiqi; Zhang, Le; (2021)
      A ppb-level H2S and CO photoacoustic spectroscopy (PAS) gas sensor was developed by using a two-stage commercial optical fiber amplifier with a full output power of 10 W. Two near-infrared diode lasers with the central wavenumbers of 6320.6 cm−1 and 6377.4 cm−1 were employed as the excitation laser source. A time-division multiplexing method was used ...
    • UBER v1.0: a universal kinetic equation solver for radiation belts 

      Zheng, Liheng; Chen, Lunjin; Chan, Anthony A.; Wang, Peng; Xia, Zhiyang; (2021)
      Recent proceedings in radiation belt studies have proposed new requirements for numerical methods to solve the kinetic equations involved. In this article, we present a numerical solver that can solve the general form of the radiation belt Fokker–Planck equation and Boltzmann equation in arbitrarily provided coordinate systems and with user-specified ...
    • Simplified Communities of Seed-Dispersers Limit the Composition and Flow of Seeds in Edge Habitats 

      Razafindratsima, Onja H.; Raoelinjanakolona, Nasandratra Nancia; Heriniaina, Rio R.; Nantenaina, Rindra H.; Ratolojanahary, Tianasoa H.; (2021)
      Edge effects, driven by human modification of landscapes, can have critical impacts on ecological processes such as species interactions, with cascading impacts on biodiversity as a whole. Characterizing how edges affect vital biotic interactions such as seed dispersal by frugivores is important for better understanding potential mechanisms that drive ...
    • Computational modeling identifies multitargeted kinase inhibitors as effective therapies for metastatic, castration-resistant prostate cancer 

      Bello, Thomas; Paindelli, Claudia; Diaz-Gomez, Luis A.; Melchiorri, Anthony; Mikos, Antonios G.; (2021)
      Castration-resistant prostate cancer (CRPC) is an advanced subtype of prostate cancer with limited therapeutic options. Here, we applied a systems-based modeling approach called kinome regularization (KiR) to identify multitargeted kinase inhibitors (KIs) that abrogate CRPC growth. Two predicted KIs, PP121 and SC-1, suppressed CRPC growth in ...
    • BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo 

      Chhabra, Sapna; Warmflash, Aryeh (2021)
      Human embryonic stem cells (hESCs) possess an immense potential to generate clinically relevant cell types and unveil mechanisms underlying early human development. However, using hESCs for discovery or translation requires accurately identifying differentiated cell types through comparison with their in vivo counterparts. Here, we set out to determine ...
    • Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis 

      Alvarado, S. K.; Miller, M. D.; Bhardwaj, M.; Thorson, J. S.; Van Lanen, S. G.; (2021)
      The 1.5 Å resolution crystal structure of DynU16, a protein identified in the dynemicin-biosynthetic gene cluster, is reported. The structure adopts a di-domain helix-grip fold with a uniquely positioned open cavity connecting the domains. The elongated dimensions of the cavity appear to be compatible with the geometry of a linear polyene, suggesting ...
    • Constraints on anomalous Higgs boson couplings to vector bosons and fermions in its production and decay using the four-lepton final state 

      CMS Collaboration (2021)
      Studies of CP violation and anomalous couplings of the Higgs boson to vector bosons and fermions are presented. The data were acquired by the CMS experiment at the LHC and correspond to an integrated luminosity of 137 fb−1 at a proton-proton collision energy of 13 TeV. The kinematic effects in the Higgs boson’s four-lepton decay H→4ℓ and its production ...
    • Search for long-lived particles decaying to jets with displaced vertices in proton-proton collisions at √s=13 TeV 

      CMS Collaboration (2021)
      A search is presented for long-lived particles produced in pairs in proton-proton collisions at the LHC operating at a center-of-mass energy of 13 TeV. The data were collected with the CMS detector during the period from 2015 through 2018, and correspond to a total integrated luminosity of 140 fb−1. This search targets pairs of long-lived particles ...
    • Integrative Generalized Convex Clustering Optimization and Feature Selection for Mixed Multi-View Data 

      Wang, Minjie; Allen, Genevera I. (2021)
      In mixed multi-view data, multiple sets of diverse features are measured on the same set of samples. By integrating all available data sources, we seek to discover common group structure among the samples that may be hidden in individualistic cluster analyses of a single data view. While several techniques for such integrative clustering have been ...
    • Impact of COVID-19 on residency choice: A survey of New York City medical students 

      Lee, Kate E.; Lim, Francesca; Silver, Elisabeth R.; Faye, Adam S.; Hur, Chin (2021)
      Objectives: The Coronavirus disease 2019 (COVID-19) pandemic disrupted medical student education, particularly in New York City (NYC). We aimed to assess the impact of the COVID-19 pandemic on medical students’ residency choices. Methods: The authors conducted a cross-sectional survey of medical students in all years of study at four NYC medical ...
    • Role of miR-2392 in driving SARS-CoV-2 infection 

      McDonald, J. Tyson; Enguita, Francisco J.; Taylor, Deanne; Griffin, Robert J.; Priebe, Waldemar; (2021)
      MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus ...
    • Health-Related Physical Fitness and Activity in Homeschool: A Systematic Review With Implications for Return to Public School 

      Kabiri, Laura S.; Messineo, Ashley; Gattu, Nikhil; Ray, Brian D.; Iammarino, Nicholas K. (2021)
      BACKGROUND: The purpose of this systematic review is to summarize what is known about health-related physical fitness (cardiovascular endurance, muscular strength and endurance, flexibility, and body composition) and physical activity among homeschool youth. Findings from this study have implications for all American youth as they return to public ...
    • A node-numbering-invariant directional length scale for simplex elements 

      Takizawa, Kenji; Ueda, Yuki; Tezduyar, Tayfun E. (2019)
      Variational multiscale methods, and their precursors, stabilized methods, have been very popular in flow computations in the past several decades. Stabilization parameters embedded in most of these methods play a significant role. The parameters almost always involve element length scales, most of the time in specific directions, such as the direction ...
    • Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections 

      Ware, Hayden H.; Kulkarni, Vikram V.; Wang, Yongxing; García, Jezreel Pantaleón; Juarez, Miguel Leiva; (2019)
      Pneumonia remains a global health threat, in part due to expanding categories of susceptible individuals and increasing prevalence of antibiotic resistant pathogens. However, therapeutic stimulation of the lungs’ mucosal defenses by inhaled exposure to a synergistic combination of Toll-like receptor (TLR) agonists known as Pam2-ODN promotes mouse ...
    • The 2016 California policy to eliminate nonmedical vaccine exemptions and changes in vaccine coverage: An empirical policy analysis 

      Nyathi, Sindiso; Karpel, Hannah C.; Sainani, Kristin L.; Maldonado, Yvonne; Hotez, Peter J.; (2019)
      Background: Vaccine hesitancy, the reluctance or refusal to receive vaccination, is a growing public health problem in the United States and globally. State policies that eliminate nonmedical (“personal belief”) exemptions to childhood vaccination requirements are controversial, and their effectiveness to improve vaccination coverage remains unclear ...