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dc.contributor.authorSohn, Yang-Sung
Tamir, Sagi
Song, Luhua
Michaeli, Dorit
Matouk, Imad
Conlan, Andrea R.
Harir, Yael
Holt, Sarah H.
Shulaev, Vladimir
Paddock, Mark L.
Hochberg, Abraham
Cabanchick, Ioav Z.
Onuchic, José N.
Jennings, Patricia A.
Nechushtai, Rachel
Mittler, Ron
dc.date.accessioned 2013-08-30T20:26:22Z
dc.date.available 2013-08-30T20:26:22Z
dc.date.issued 2013
dc.identifier.citation Sohn, Yang-Sung, Tamir, Sagi, Song, Luhua, et al.. "NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth." PNAS Early Edition, (2013) http://dx.doi.org/10.1073/pnas.1313198110.
dc.identifier.urihttp://hdl.handle.net/1911/71866
dc.description.abstract Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy.
dc.language.iso eng
dc.title NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth
dc.type Journal article
dc.contributor.funder Cancer Prevention and Research Institute of Texas
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle PNAS Early Edition
dc.contributor.org Center for Theoretical Biological Physics
dc.subject.keywordCisd1
Cisd2
Miner1
MCF7
MDA-MB-231
dc.contributor.publisher National Academy of Sciences
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.1313198110
dc.identifier.pmcid PMC3767537
dc.identifier.pmid 23959881
dc.identifier.grantID GM54038 (National Institutes of Health)
dc.identifier.grantID GM101467 (National Institutes of Health)
dc.type.publication publisher version


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