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dc.contributor.authorCordray, Michael S.
Richards-Kortum, Rebecca R.
dc.date.accessioned 2013-07-12T21:23:25Z
dc.date.available 2013-07-12T21:23:25Z
dc.date.issued 2012
dc.identifier.citation Cordray, Michael S. and Richards-Kortum, Rebecca R.. "Review: Emerging Nucleic Acid-Based Tests for Point-of-Care Detection of Malaria." American Journal of Tropical Medicine and Hygiene, 87, no. 2 (2012) The American Society of Tropical Medicine and Hygiene: 223-230. http://dx.doi.org/10.4269/ajtmh.2012.11-0685.
dc.identifier.urihttps://hdl.handle.net/1911/71558
dc.description.abstract Malaria remains a serious disease in the developing world. There is a growing consensus that new diagnostics are needed in low-resource settings. The ideal malaria diagnostic should be able to speciate; measure parasitemia; low-cost, quick, and simple to use; and capable of detecting low-level infections. A promising development are nucleic acid tests (NATs) for the diagnosis of malaria, which are well suited for point-of-care use because of their ability to detect low-level infections and speciate, and because they have high sensitivity and specificity. The greatest barrier to NAT use in the past has been its relatively high cost, and the amount of infrastructure required in the form of equipment, stable power, and reagent storage. This review describes recent developments to decrease the cost and run time, and increase the ease of use of NAT while maintaining their high sensitivity and specificity and low limit of detection at the point-of-care.
dc.language.iso eng
dc.publisher The American Society of Tropical Medicine and Hygiene
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Review: Emerging Nucleic Acid-Based Tests for Point-of-Care Detection of Malaria
dc.type Journal article
dc.contributor.funder Bill and Melinda Gates Foundation
dc.citation.journalTitle American Journal of Tropical Medicine and Hygiene
dc.citation.volumeNumber 87
dc.citation.issueNumber 2
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.4269/ajtmh.2012.11-0685
dc.identifier.pmcid PMC3414556
dc.identifier.pmid 22855751
dc.identifier.grantID Grand Challenges Explorations Initiative (Bill and Melinda Gates Foundation)
dc.type.publication publisher version
dc.citation.firstpage 223
dc.citation.lastpage 230


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