Show simple item record

dc.contributor.authorHu, Bo
Kessler, David A.
Rappel, Wouter-Jan
Levine, Herbert
dc.date.accessioned 2013-07-12T20:09:30Z
dc.date.available 2013-07-12T20:09:30Z
dc.date.issued 2012
dc.identifier.citation Hu, Bo, Kessler, David A., Rappel, Wouter-Jan, et al.. "How input fluctuations reshape the dynamics of a biological switching system." Physical Review E, 86, (2012) 061910. http://dx.doi.org/10.1103/PhysRevE.86.061910.
dc.identifier.urihttps://hdl.handle.net/1911/71549
dc.description.abstract An important task in quantitative biology is to understand the role of stochasticity in biochemical regulation. Here, as an extension of our recent work [Phys. Rev. Lett. 107, 148101 (2011)], we study how input fluctuations affect the stochastic dynamics of a simple biological switch. In our model, the on transition rate of the switch is directly regulated by a noisy input signal, which is described as a non-negative mean-reverting diffusion process. This continuous process can be a good approximation of the discrete birth-death process and is much more analytically tractable.Within this setup, we apply the Feynman-Kac theorem to investigate the statistical features of the output switching dynamics. Consistent with our previous findings, the input noise is found to effectively suppress the input-dependent transitions.We show analytically that this effect becomes significant when the input signal fluctuates greatly in amplitude and reverts slowly to its mean.
dc.language.iso eng
dc.title How input fluctuations reshape the dynamics of a biological switching system
dc.type Journal article
dc.contributor.funder National Science Foundation
dc.citation.journalTitle Physical Review E
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 86
dc.contributor.publisher American Physical Society
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.86.061910
dc.identifier.grantID PHY-0822283 (National Science Foundation)
dc.citation.firstpage 061910


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record