|dc.contributor.author||Schnur, Tatiana T.
Schwartz, Myrna F.
Kimberg, Daniel Y.
Coslett, H. Branch
Thompson-Schill, Sharon L.
In order to produce a word, the intended word must be selected from a competing set of other
words. In other domains where competition affects the selection process, the left inferior frontal
gyrus (LIFG) responds to competition among incompatible representations. The aim of this study
was to test whether the LIFG is necessary for resolution of competition in word production.
Using a novel methodological approach applying the same rigorous analytic methods to
neuropsychological data as is done with neuroimaging data, we compared brain activation
patterns in normal speakers (using fMRI) with the results of lesion-deficit correlations in aphasic
speakers who performed the same word production task designed to elicit competition during
lexical selection. The degree of activation of the LIFG in normal speakers and damage to the
LIFG in aphasic speakers was associated with performance on the production task. These
convergent findings provide strong support for the hypothesis that the region of cortex
commonly known as Broca's area (i.e., the posterior LIFG) serves to bias competitive
interactions during language production.
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the National Academy of Science.
Localizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Area
National Institutes of Health
left inferior frontal gyrus
National Academy of Science
HD007425 (National Institutes of Health)
Schnur, Tatiana T., Schwartz, Myrna F., Kimberg, Daniel Y., et al., . "Localizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Area." PNAS, 106, no. 1 (2009) 322-327. http://dx.doi.org/10.1073/pnas.0805874106.