Show simple item record

dc.contributor.authorSchnur, Tatiana T.
Schwartz, Myrna F.
Kimberg, Daniel Y.
Hirshorn, Elizabeth
Coslett, H. Branch
Thompson-Schill, Sharon L.
dc.date.accessioned 2013-05-09T19:52:41Z
dc.date.available 2013-05-09T19:52:41Z
dc.date.issued 2009
dc.identifier.urihttp://hdl.handle.net/1911/71109
dc.description.abstract In order to produce a word, the intended word must be selected from a competing set of other words. In other domains where competition affects the selection process, the left inferior frontal gyrus (LIFG) responds to competition among incompatible representations. The aim of this study was to test whether the LIFG is necessary for resolution of competition in word production. Using a novel methodological approach applying the same rigorous analytic methods to neuropsychological data as is done with neuroimaging data, we compared brain activation patterns in normal speakers (using fMRI) with the results of lesion-deficit correlations in aphasic speakers who performed the same word production task designed to elicit competition during lexical selection. The degree of activation of the LIFG in normal speakers and damage to the LIFG in aphasic speakers was associated with performance on the production task. These convergent findings provide strong support for the hypothesis that the region of cortex commonly known as Broca's area (i.e., the posterior LIFG) serves to bias competitive interactions during language production.
dc.language.iso eng
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the National Academy of Science.
dc.title Localizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Area
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle PNAS
dc.subject.keywordaphasia
language production
left inferior frontal gyrus
lexical competition
dc.citation.volumeNumber 106
dc.citation.issueNumber 1
dc.contributor.publisher National Academy of Science
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.0805874106
dc.identifier.pmcid PMC2629229
dc.identifier.pmid 19118194
dc.identifier.grantID HD007425 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 322
dc.citation.lastpage 327
dc.identifier.citation Schnur, Tatiana T., Schwartz, Myrna F., Kimberg, Daniel Y., et al., . "Localizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Area." PNAS, 106, no. 1 (2009) 322-327. http://dx.doi.org/10.1073/pnas.0805874106.


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record