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dc.contributor.authorBjorum, Sonia M.
Simonette, Rebecca A.
Alanis, Raul Jr.
Wang, Jennifer E.
Lewis, Benjamin M.
Trejo, Michael H.
Hanson, Keith A.
Beckingham, Kathleen M.
dc.date.accessioned 2013-04-29T20:16:15Z
dc.date.available 2013-04-29T20:16:15Z
dc.date.issued 2013
dc.identifier.citation Bjorum, Sonia M., Simonette, Rebecca A., Alanis, Raul Jr., et al.. "The Drosophila BTB Domain Protein Jim Lovell Has Roles in Multiple Larval and Adult Behaviors." PLoS One, 8, no. 4 (2013) e61270. http://dx.doi.org/10.1371/journal.pone.0061270.
dc.identifier.urihttp://hdl.handle.net/1911/71022
dc.description.abstract Innate behaviors have their origins in the specification of neural fates during development. Within Drosophila, BTB (Bric-abrac, Tramtrack, Broad) domain proteins such as Fruitless are known to play key roles in the neural differentiation underlying such responses. We previously identified a gene, which we have termed jim lovell (lov), encoding a BTB protein with a role in gravity responses. To understand more fully the behavioral roles of this gene we have investigated its function through several approaches. Transcript and protein expression patterns have been examined and behavioral phenotypes of new lov mutations have been characterized. Lov is a nuclear protein, suggesting a role as a transcriptional regulator, as for other BTB proteins. In late embryogenesis, Lov is expressed in many CNS and PNS neurons. An examination of the PNS expression indicates that lov functions in the late specification of several classes of sensory neurons. In particular, only two of the five abdominal lateral chordotonal neurons express Lov, predicting functional variation within this highly similar group. Surprisingly, Lov is also expressed very early in embryogenesis in ways that suggests roles in morphogenetic movements, amnioserosa function and head neurogenesis. The phenotypes of two new lov mutations that delete adjacent non-coding DNA regions are strikingly different suggesting removal of different regulatory elements. In lov47, Lov expression is lost in many embryonic neurons including the two lateral chordotonal neurons. lov47 mutant larvae show feeding and locomotor defects including spontaneous backward movement. Adult lov47 males perform aberrant courtship behavior distinguished by courtship displays that are not directed at the female. lov47 adults also show more defective negative gravitaxis than the previously isolated lov91Y mutant. In contrast, lov66 produces largely normal behavior but severe female sterility associated with ectopic lov expression in the ovary. We propose a negative regulatory role for the DNA deleted in lov66.
dc.language.iso eng
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.title The Drosophila BTB Domain Protein Jim Lovell Has Roles in Multiple Larval and Adult Behaviors
dc.type Journal article
dc.contributor.funder National Aeronautics and Space Administration
dc.citation.journalTitle PLoS One
dc.citation.volumeNumber 8
dc.citation.issueNumber 4
dc.contributor.publisher Public Library of Science
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0061270
dc.identifier.pmcid PMC3631165
dc.identifier.pmid 23620738
dc.identifier.grantID NNX09AH43G (National Aeronautics and Space Administration)
dc.type.publication publisher version
dc.citation.firstpage e61270


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.