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dc.contributor.authorSalter, Mallory D.
Blouin, George C.
Soman, Jayashree
Singleton, Eileen W.
Dewilde, Sylvia
Moens, Luc
Pesce, Alessandra
Nardini, Marco
Bolognesi, Martino
Olson, John S.
dc.date.accessioned 2013-03-21T14:43:42Z
dc.date.available 2014-03-22T05:10:04Z
dc.date.issued 2012
dc.identifier.urihttp://hdl.handle.net/1911/70807
dc.description.abstract Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry.
dc.language.iso eng
dc.title Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.contributor.funder Welch Foundation
dc.citation.journalTitle The Journal of Biological Chemistry
dc.citation.volumeNumber 287
dc.citation.issueNumber 40
dc.contributor.publisher The American Society for Biochemistry and Molecular Biology, Inc.
dc.embargo.terms 1 year
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1074/jbc.M112.392258
dc.identifier.pmcid PMC3460423
dc.identifier.pmid 22859299
dc.identifier.grantID GM035649 (National Institutes of Health)
dc.identifier.grantID HL047020 (National Institutes of Health)
dc.identifier.grantID C-0612 (Welch Foundation)
dc.type.publication publisher version
dc.citation.firstpage 33163
dc.citation.lastpage 33178
dc.identifier.citation Salter, Mallory D., Blouin, George C., Soman, Jayashree, et al., . "Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates." The Journal of Biological Chemistry, 287, no. 40 (2012) 33163-33178. http://dx.doi.org/10.1074/jbc.M112.392258.


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