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dc.contributor.authorPetsche, Jennifer J.
Camci-Unal, Gulden
Khademhosseini, Ali
Jacot, Jeffrey G.
dc.date.accessioned 2013-03-18T20:46:39Z
dc.date.available 2013-03-18T20:46:39Z
dc.date.issued 2013
dc.identifier.citation Petsche, Jennifer J., Camci-Unal, Gulden, Khademhosseini, Ali, et al.. "Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications." Tissue Engineering Part B: Reviews, (2013) Mary Ann Liebert, Inc.: http://dx.doi.org/10.1089/ten.TEB.2012.0561.
dc.identifier.urihttps://hdl.handle.net/1911/70702
dc.description.abstract Recent research has demonstrated that a population of stem cells can be isolated from amniotic fluid removed by amniocentesis that are broadly multipotent and non-tumorogenic. These amniotic fluid-derived stem cells (AFSC) could potentially provide an autologous cell source for treatment of congenital defects identified during gestation, particularly cardiovascular defects. In this review, the various methods of isolating, sorting and culturing AFSC are compared, along with techniques for inducing differentiation into cardiac myocytes and endothelial cells. Though research has not demonstrated complete and high yield cardiac differentiation, AFSC have been shown to effectively differentiate into endothelial cells and can effectively support cardiac tissue. Additionally, several tissue engineering and regenerative therapeutic approaches for the use of these cells in heart patches, injection after myocardial infarction, heart valves, vascularized scaffolds and blood vessels are summarized. These applications show great promise in the treatment of congenital cardiovascular defects, and further studies of isolation, culture, and differentiation of AFSC will help to develop their use for tissue engineering, regenerative medicine, and cardiovascular therapies.
dc.language.iso eng
dc.publisher Mary Ann Liebert, Inc.
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Mary Ann Liebert, Inc.
dc.title Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications
dc.type Journal article
dc.contributor.funder National Science Foundation
dc.contributor.funder American Heart Association
dc.citation.journalTitle Tissue Engineering Part B: Reviews
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1089/ten.TEB.2012.0561
dc.identifier.pmcid PMC3690092
dc.identifier.pmid 23350771
dc.identifier.grantID GRFP 0940902 (National Science Foundation)
dc.identifier.grantID CAREER (National Science Foundation)
dc.identifier.grantID Beginning Grant-in-Aid (American Heart Association)
dc.type.publication post-print


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