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dc.contributor.advisor Massoud, Yehia
dc.creatorDev, Kapil
dc.date.accessioned 2013-03-08T00:33:20Z
dc.date.available 2013-03-08T00:33:20Z
dc.date.issued 2012
dc.identifier.urihttps://hdl.handle.net/1911/70227
dc.description.abstract With the continuous research and advances in Deoxyribonucleic acid (DNA) sequencing technologies, the need for an efficient DNA shearing system has increased more than ever before. In this thesis, we propose a fast, efficient and controlled DNA shearing system based on a uniquely designed ultrasonic transducer, called Fresnel Annular Sector Actuator (FASA). Based on the simulation and experimental results, a circular array of four 90°-FASA elements is chosen as the basic unit for the proposed shearing system. DNA is successfully sheared from 300 to 1500 base-pair lengths. The shearing performance of the system is independent of the source of DNA over a large range of concentrations of the DNA. Finally, multiple FASA elements, excited by separate BF-signals, are used to increase the throughput of the proposed shearing system.
dc.format.extent 96 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectApplied sciences
Biomedical engineering
Electrical engineering
dc.title Design of a Fast, Efficient and Controlled DNA Shearing System Based on Lateral Acoustic Waves
dc.identifier.digital DevK
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Electrical and Computer Engineering
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.identifier.citation Dev, Kapil. "Design of a Fast, Efficient and Controlled DNA Shearing System Based on Lateral Acoustic Waves." (2012) Master’s Thesis, Rice University. https://hdl.handle.net/1911/70227.


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