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dc.contributor.authorLukianova-Hleb, Ekaterina Y.
Ren, Xiaoyang
Townley, Debra
Wu, Xiangwei
Kupferman, Michael E.
dc.date.accessioned 2013-01-09T19:09:50Z
dc.date.available 2013-01-09T19:09:50Z
dc.date.issued 2012
dc.identifier.citation Lukianova-Hleb, Ekaterina Y., Ren, Xiaoyang, Townley, Debra, et al.. "Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors." Theranostics, 2, no. 10 (2012) 976-987. http://dx.doi.org/10.7150/thno.5116.
dc.identifier.urihttp://hdl.handle.net/1911/68530
dc.description.abstract The resistance of residual cancer cells after oncological resection to adjuvant chemoradiotherapies results in both high recurrence rates and high non-specific tissue toxicity, thus preventing the successful treatment of such cancers as head and neck squamous cell carcinoma (HNSCC). The patients' survival rate and quality of life therefore depend upon the efficacy, selectivity and low non-specific toxicity of the adjuvant treatment. We report a novel, theranostic in vivo technology that unites both the acoustic diagnostics and guided intracellular delivery of anti-tumor drug (liposome-encapsulated doxorubicin, Doxil) in one rapid process, namely a pulsed laser-activated plasmonic nanobubble (PNB). HNSCC-bearing mice were treated with gold nanoparticle conjugates, Doxil, and single near-infrared laser pulses of low energy. Tumor-specific clusters of gold nanoparticles (solid gold spheres) converted the optical pulses into localized PNBs. The acoustic signals of the PNB detected the tumor with high specificity and sensitivity. The mechanical impact of the PNB, co-localized with Doxil liposomes, selectively ejected the drug into the cytoplasm of cancer cells. Cancer cell-specific generation of PNBs and their intracellular co-localization with Doxil improved the in vivo therapeutic efficacy from 5-7% for administration of only Doxil or PNBs alone to 90% thus demonstrating the synergistic therapeutic effect of the PNB-based intracellular drug release. This mechanism also reduced the non-specific toxicity of Doxil below a detectable level and the treatment time to less than one minute. Thus PNBs combine highly sensitive diagnosis, overcome drug resistance and minimize non-specific toxicity in a single rapid theranostic procedure for intra-operative treatment.
dc.language.iso eng
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.title Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors
dc.type Journal article
dc.citation.journalTitle Theranostics
dc.citation.volumeNumber 2
dc.citation.issueNumber 10
dc.contributor.publisher Ivyspring International Publisher
dc.embargo.terms none
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.7150/thno.5116
dc.identifier.pmcid PMC3493199
dc.identifier.pmid 23139725
dc.type.publication publisher version
dc.citation.firstpage 976
dc.citation.lastpage 987


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This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.