Now showing items 1-20 of 72

    • Amplification of USP13 drives ovarian cancer metabolism 

      Han, Cecil; Yang, Lifeng; Choi, Hyun Ho; Baddour, Joelle; Achreja, Abhinav; Liu, Yunhua; Li, Yujing; Li, Jiada; Wan, Guohui; Huang, Cheng; Ji, Guang; Zhang, Xinna; Nagrath, Deepak; Lu, Xiongbin (2016)
      Dysregulated energetic metabolism has been recently identified as a hallmark of cancer. Although mutations in metabolic enzymes hardwire metabolism to tumourigenesis, they are relatively infrequent in ovarian cancer. More ...
    • Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals 

      Clomburg, James M.; Gonzalez, Ramon (2013-01)
      To ensure the long-term viability of biorefineries, it is essential to go beyond the carbohydrate-based platform and develop complementing technologies capable of producing fuels and chemicals from a wide array of available ...
    • Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart 

      Pok, Seokwon; Vitale, Flavia; Eichmann, Shannon L.; Benavides, Omar M.; Pasquali, Matteo; Jacot, Jeffrey G. (2014)
      The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal ...
    • Carbon nanotube woven textile photodetector 

      Zubair, Ahmed; Wang, Xuan; Mirri, Francesca; Tsentalovich, Dmitri E.; Fujimura, Naoki; Suzuki, Daichi; Soundarapandian, Karuppasamy P.; Kawano, Yukio; Pasquali, Matteo; Kono, Junichiro (2018)
      The increasing interest in mobile and wearable technology demands the enhancement of functionality of clothing through incorporation of sophisticated architectures of multifunctional materials. Flexible electronic and ...
    • Charged iodide in chains behind the highly efficient iodine doping in carbon nanotubes 

      Zubair, Ahmed; Tristant, Damien; Nie, Chunyang; Tsentalovich, Dmitri E.; Headrick, Robert J.; Pasquali, Matteo; Kono, Junichiro; Meunier, Vincent; Flahaut, Emmanuel; Monthioux, Marc; Gerber, Iann C.; Puech, Pascal (2017)
      The origin of highly efficient iodine doping of carbon nanotubes is not well understood. Relying on first-principles calculations, we found that iodine molecules (I2) in contact with a carbon nanotube interact to form ...
    • Competing mechanisms and scaling laws for carbon nanotube scission by ultrasonication 

      Pagani, Guido; Green, Micah J.; Poulin, Philippe; Pasquali, Matteo (2012)
      Dispersion of carbon nanotubes (CNTs) into liquids typically requires ultrasonication to exfoliate individuals CNTs from bundles. Experiments show that CNT length drops with sonication time (or energy) as a power law t?m. ...
    • A density functional theory for patchy colloids based on Wertheim's association theory: Beyond the single bonding condition 

      Marshall, Bennett D.; Chapman, Walter G. (2013)
      In the framework of Wertheimメs theory, we develop the first classical density functional theory for patchy colloids where the patch can bond more than once. To test the theory we perform new Monte Carlo simulations for the ...
    • Differential Effect of Culture Temperature and Specific Growth Rate on CHO Cell Behavior in Chemostat Culture 

      Vergara, Mauricio; Becerra, Silvana; Berrios, Julio; Osses, Nelson; Reyes, Juan; Rodriguez-Moya, Maria; Gonzalez, Ramon; Altamirano, Claudia (2014)
      Mild hypothermia condition in mammalian cell culture technology has been one of the main focuses of research for the development of breeding strategies to maximize productivity of these production systems. Despite the large ...
    • Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli 

      Mazumdar, Suman; Blankschien, Matthew D; Clomburg, James M; Gonzalez, Ramon (2013)
      Due to its abundance and low-price, glycerol has become an attractive carbon source for the industrial production of value-added fuels and chemicals. This work reports the engineering of E. coli for the efficient conversion ...
    • Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures 

      Vergara, Mauricio; Berrios, Julio; Martínez, Irene; Díaz-Barrera, Alvaro; Acevedo, Cristian; Reyes, Juan G.; Gonzalez, Ramon; Altamirano, Claudia (2015)
      Background: Chinese hamster ovary (CHO) cells are the main host for producing recombinant proteins with human therapeutic applications mainly because of their capability to perform proper folding and glycosylation processes. ...
    • Experimental realization of crossover in shape and director field of nematic tactoids 

      Jamali, Vida; Behabtu, Natnael; Senyuk, Bohdan; Lee, J. Alex; Smalyukh, Ivan I.; van der Schoot, Paul; Pasquali, Matteo (2015)
      Spindle-shaped nematic droplets (tactoids) form in solutions of rod-like molecules at the onset of the liquid crystalline phase. Their unique shape and internal structure result from the interplay of the elastic deformation ...
    • Fabrication and characterization of multiscale electrospun scaffolds for cartilage regeneration 

      Levorson, Erica J.; Sreerekha, Perumcherry Raman; Chennazhi, Krishna Prasad; Kasper, F. Kurtis; Nair, Shantikumar V.; Mikos, Antonios G. (2013)
      Recently, scaffolds for tissue regeneration purposes have been observed to utilize nanoscale features in an effort to reap the cellular benefits of scaffold features resembling extracellular matrix (ECM) components. However, ...
    • Facile Graphene Oxide Preparation by Microwave-Assisted Acid Method 

      Viana, Marcelo M.; Lima, Meiriane C.F.S.; Forsythe, Jerimiah C.; Gangoli, Varun S.; Cho, Minjung; Cheng, Yinhong; Silva, Glaura G.; Wong, Michael S.; Caliman, Vinicius (2015)
      Few-layered graphene oxide (GO) was prepared using a fast and energy-saving method by microwave-assisted acid technique. The oxygenated groups existing on the GO surface were determined using UV-Vis, X-ray photoelectron ...
    • From strings to coils: Rotational dynamics of DNA-linked colloidal chains 

      Kuei, Steve; Garza, Burke; Biswal, Sibani Lisa (2017)
      We investigate the dynamical behavior of deformable filaments experimentally using a tunable model system consisting of linked paramagnetic colloidal particles, where the persistence length lp, the contour length lc, and ...
    • Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein 

      Kilpatrick, Kiri; Zeng, Yimeng; Hancock, Tommy; Segatori, Laura (2015)
      Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson’s disease (PD). The formation of α-syn aggregates results from aberrant accumulation of ...
    • Highly Flexible Self-Assembled V2O5 Cathodes Enabled by Conducting Diblock Copolymers 

      An, Hyosung; Mike, Jared; Smith, Kendall A.; Swank, Lisa; Lin, Yen-Hao; Pesek, Stacy L.; Verduzco, Rafael; Lutkenhaus, Jodie L. (2015)
      Mechanically robust battery electrodes are desired for applications in wearable devices, flexible displays, and structural energy and power. In this regard, the challenge is to balance mechanical and electrochemical ...
    • HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer 

      Mondal, Susmita; Roy, Debarshi; Camacho-Pereira, Juliana; Khurana, Ashwani; Chini, Eduardo; Yang, Lifeng; Baddour, Joelle; Stilles, Katherine; Padmabandu, Seth; Leung, Sam; Kalloger, Steve; Gilks, Blake; Lowe, Val; Dierks, Thomas; Hammond, Edward; Dredge, Keith; Nagrath, Deepak; Shridhar, Viji (2015)
      Warburg effect has emerged as a potential hallmark of many cancers. However, the molecular mechanisms that led to this metabolic state of aerobic glycolysis, particularly in ovarian cancer (OVCA) have not been completely ...
    • Human Omental-Derived Adipose Stem Cells Increase Ovarian Cancer Proliferation, Migration, and Chemoresistance 

      Nowicka, Aleksandra; Marini, Frank C.; Solley, Travis N.; Elizondo, Paula B.; Zhang, Yan; Sharp, Hadley J.; Broaddus, Russell; Kolonin, Mikhail; Mok, Samuel C.; Thompson, Melissa S.; Woodward, Wendy A.; Lu, Karen; Salimian, Bahar; Nagrath, Deepak; Klopp, Ann H. (2013)
      Objectives: Adipose tissue contains a population of multipotent adipose stem cells (ASCs) that form tumor stroma and can promote tumor progression. Given the high rate of ovarian cancer metastasis to the omental adipose, ...
    • Hydrophobic and hydrophilic interactions in aqueous mixtures of alcohols at a hydrophobic surface 

      Ballal, Deepti; Chapman, Walter G. (2013)
      Aqueous solutions of alcohols are interesting because of their anomalous behavior that is believed to be due to the molecular structuring of water and alcohol around each other in solution. The interfacial structuring and ...
    • The impact of lithologic heterogeneity and focused fluid flow upon gas hydrate distribution in marine sediments 

      Chatterjee, Sayantan; Bhatnagar, Gaurav; Dugan, Brandon; Dickens, Gerald R.; Chapman, Walter G.; Hirasaki, George J. (2014)
      Gas hydrate and free gas accumulation in heterogeneous marine sediment is simulated using a two-dimensional (2-D) numerical model that accounts for mass transfer over geological timescales. The model extends a previously ...