Now showing items 1-1 of 1

    • In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia 

      Pan Xiaolu; Philippen Leonne; Lahiri Satadru K.; Lee Ciaran; Park So Hyun; Word Tarah A.; Li Na; Jarrett Kelsey E.; Gupta Rajat; Reynolds Julia O.; Lin Jean; Bao Gang; Lagor William R.; Wehrens Xander H.T. (2018)
      Rationale:Autosomal-dominant mutations in ryanodine receptor type 2 (RYR2) are responsible for ≈60% of all catecholaminergic polymorphic ventricular tachycardia. Dysfunctional RyR2 subunits trigger inappropriate calcium ...