Now showing items 162-176 of 176

  • TFEB regulates lysosomal proteostasis 

    Song, Wensi; Wang, Fan; Savini, Marzia; Ake, Ashley; di Ronza, Alberto; Sardiello, Marco; Segatori, Laura (2013)
    Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding ...
  • TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds 

    Dahlin, Rebecca L.; Ni, Mengwei; Meretoja, Ville V.; Kasper, F. Kurtis; Mikos, Antonios G. (2014)
    In this work, it was hypothesized that co-cultures of articular chondrocytes (ACs) and mesenchymal stem cells (MSCs) would exhibit enhanced sensitivity to chondrogenic stimuli, such as TGF-β3, and would require a reduced ...
  • Three-dimensional in vitro tumor models for cancer research and drug evaluation 

    Xu, Xian; Farach-Carson, Mary C.; Jia, Xinqiao (2014)
    Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy metabolism and evade immune destruction, leading to ...
  • Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration 

    Hoffmann, Joseph C.; West, Jennifer L. (2013)
    In order to independently study the numerous variables that influence cell movement, it will be necessary to employ novel tools and materials that allow for exquisite control of the cellular microenvironment. In this ...
  • The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition 

    Huang, Bin; Lu, Mingyang; Jolly, Mohit Kumar; Tsarfaty, Ilan; Onuchic, José; Ben-Jacob, Eshel (2014-09-23)
    Metastatic carcinoma cells exhibit at least two different phenotypes of motility and invasion - amoeboid and mesenchymal. This plasticity poses a major clinical challenge for treating metastasis, while its underlying ...
  • Tissue engineering perfusable cancer models 

    Fong, E.L.; Santoro, M.; Farach-Carson, M.C.; Kasper, F.K.; Mikos, A.G. (2014)
    The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be ...
  • Tunable optical tweezers for wavelength-dependent measurements 

    Hester, Brooke; Campbell, Gretchen K.; Lopez-Mariscal, Carlos; Filgueira, Carly Levin; Huschka, Ryan; Halas, Naomi J.; Helmerson, Kristian (2012)
    Optical trapping forces depend on the difference between the trap wavelength and the extinction resonances of trapped particles. This leads to a wavelength-dependent trapping force, which should allow for the optimization ...
  • Tunable Protease-Activatable Virus Nanonodes 

    Judd, Justin; Ho, Michelle L.; Tiwari, Abhinav; Gomez, Eric J.; Dempsey, Christopher; Vliet, Kim Van; Igoshin, Oleg A.; Silberg, Jonathan J.; Agbandje-McKenna, Mavis; Suh, Junghae (2014)
    We explored the unique signal integration properties of the self-assembling 60-mer protein capsid of adeno-associated virus (AAV), a clinically proven human gene therapy vector, by engineering proteolytic regulation of ...
  • Ultrasensitivity of the Bacillus subtilis sporulation decision 

    Narula, Jatin; Devi, Seram N.; Fujita, Masaya; Igoshin, Oleg A. (2012-11-19)
    Starving Bacillus subtilis cells execute a gene expression program resulting in the formation of stress-resistant spores. Sporulation master regulator, Spo0A, is activated by a phosphorelay and controls the expression ...
  • Ultraspecific and Highly Sensitive Nucleic Acid Detection by Integrating a DNA Catalytic Network with a Label-Free Microcavity 

    Wu, Yuqiang; Zhang, David Yu; Yin, Peng; Vollmer, Frank (2014)
    Nucleic acid detection with label-free biosensors circumvents costly fluorophore functionalization steps associated with conventional assays by utilizing transducers of impressive ultimate detection limits. Despite this ...
  • Unraveling the regulatory connections between two controllers of breast cancer cell fate 

    Lee, Jinho; Tiwari, Abhinav; Shum, Victor; Mills, Gordon B.; Mancini, Michael A.; Igoshin, Oleg A.; Balázsi, Gábor (2014)
    Estrogen receptor alpha (ERα) expression is critical for breast cancer classification, high ERα expression being associated with better prognosis. ERα levels strongly correlate with that of GATA binding protein 3 (GATA3), ...
  • Use of Myocardial Matrix in a Chitosan-Based Full-Thickness Heart Patch 

    Pok, Seokwon; Benavides, Omar M.; Hallal, Patrick; Jacot, Jeffrey G. (2014)
    A novel cardiac scaffold comprised of decellularized porcine heart matrix was investigated for use as a biodegradable patch with a potential for surgical reconstruction of the right ventricular outflow tract. Powdered heart ...
  • Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison 

    Fouad, Anthony; Pfefer, T. Joshua; Chen, Chao-Wei; Gong, Wei; Agrawal, Anant; Tomlins, Peter H.; Woolliams, Peter D.; Drezek, Rebekah A.; Chen, Yu (2014)
    Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across ...
  • Vital-dye-enhanced multimodal imaging of neoplastic progression in a mouse model of oral carcinogenesis 

    Hellebust, Anne; Rosbach, Kelsey; Wu, Jessica Keren; Nguyen, Jennifer; Gillenwater, Ann; Vigneswaran, Nadarajah; Richards-Kortum, Rebecca (2013)
    In this longitudinal study, a mouse model of 4-nitroquinoline 1-oxide chemically induced tongue carcinogenesis was used to assess the ability of optical imaging with exogenous and endogenous contrast to detect neoplastic ...
  • Why Zeolites Have So Few 7-Membered Rings 

    Li, Xi; Deem, Michael W. (2014)
    Known zeolite structures have relatively few 7-membered rings. Previous quantum mechanical calculations suggest there is no particular energy penalty for 7-membered rings. Predicted zeolite structures sampled from all ...