Now showing items 67-71 of 71

  • TFEB regulates lysosomal proteostasis 

    Song, Wensi; Wang, Fan; Savini, Marzia; Ake, Ashley; di Ronza, Alberto; Sardiello, Marco; Segatori, Laura (2013)
    Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding ...
  • The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition 

    Huang, Bin; Lu, Mingyang; Jolly, Mohit Kumar; Tsarfaty, Ilan; Onuchic, José; Ben-Jacob, Eshel (2014-09-23)
    Metastatic carcinoma cells exhibit at least two different phenotypes of motility and invasion - amoeboid and mesenchymal. This plasticity poses a major clinical challenge for treating metastasis, while its underlying ...
  • Tunable optical tweezers for wavelength-dependent measurements 

    Hester, Brooke; Campbell, Gretchen K.; Lopez-Mariscal, Carlos; Filgueira, Carly Levin; Huschka, Ryan; Halas, Naomi J.; Helmerson, Kristian (2012)
    Optical trapping forces depend on the difference between the trap wavelength and the extinction resonances of trapped particles. This leads to a wavelength-dependent trapping force, which should allow for the optimization ...
  • Ultrasensitivity of the Bacillus subtilis sporulation decision 

    Narula, Jatin; Devi, Seram N.; Fujita, Masaya; Igoshin, Oleg A. (2012-11-19)
    Starving Bacillus subtilis cells execute a gene expression program resulting in the formation of stress-resistant spores. Sporulation master regulator, Spo0A, is activated by a phosphorelay and controls the expression ...
  • Use of Myocardial Matrix in a Chitosan-Based Full-Thickness Heart Patch 

    Pok, Seokwon; Benavides, Omar M.; Hallal, Patrick; Jacot, Jeffrey G. (2014)
    A novel cardiac scaffold comprised of decellularized porcine heart matrix was investigated for use as a biodegradable patch with a potential for surgical reconstruction of the right ventricular outflow tract. Powdered heart ...