Now showing items 417-436 of 456

    • Total Synthesis of Myceliothermophins C, D and E 

      Nicolaou, K.C.; Shi, Lei; Lu, Min; Pattanayak, Manas R.; Shah, Akshay A.; Ioannidou, Heraklidia A.; Lamani, Manjunath (2014)
      The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three ...
    • Total Synthesis of Viridicatumtoxin B and Analogues Thereof: Strategy Evolution, Structural Revision, and Biological Evaluation 

      Nicolaou, K.C.; Hale, Christopher R.H.; Nilewski, Christian; Ioannidou, Heraklidia A.; ElMarrouni, Abdelatif; Nilewski, Lizanne G.; Beabout, Kathryn; Wang, Tim T.; Shamoo, Yousif (2014)
      The details of the total synthesis of viridicatumtoxin B (1) are described. Initial synthetic strategies toward this intriguing tetracycline antibiotic resulted in the development of key alkylation and Lewis acid-mediated ...
    • Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent 

      Nicolaou, K.C.; Heretsch, Philipp; ElMarrouni, Abdelatif; Hale, Christopher R.H.; Pulukuri, Kiran K.; Kudva, Avinash K.; Narayan, Vivek; Prabhu, K. Sandeep (2014)
      A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively ...
    • Toward carbon nanotube-based imaging agents for the clinic 

      Hernández-Rivera, Mayra; Zaibaq, Nicholas G.; Wilson, Lon J. (2016)
      Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical ...
    • Toward Practical Non-Contact Optical Strain Sensing Using Single-Walled Carbon Nanotubes 

      Sun, Peng; Bachilo, Sergei M.; Nagarajaiah, Satish; Weisman, R. Bruce (2016)
      Progress is reported in an emerging non-contact strain sensing technology based on optical properties of single-walled carbon nanotubes (SWCNTs). In this strain-sensing smart skin (“S4”) method, nanotubes are dilutely ...
    • Towards the Solution of the Many-Electron Problem in Real Materials: Equation of State of the Hydrogen Chain with State-of-the-Art Many-Body Methods 

      Motta, Mario; Ceperley, David M.; Chan, Garnet Kin-Lic; Gomez, John A.; Gull, Emanuel; Guo, Sheng; Jiménez-Hoyos, Carlos A.; Lan, Tran Nguyen; Li, Jia; Ma, Fengjie; Millis, Andrew J.; Prokof’ev, Nikolay V.; Ray, Ushnish; Scuseria, Gustavo E.; Sorella, Sandro; Stoudenmire, Edwin M.; Sun, Qiming; Tupitsyn, Igor S.; White, Steven R.; Zgid, Dominika; Zhang, Shiwei (2017)
      We present numerical results for the equation of state of an infinite chain of hydrogen atoms. A variety of modern many-body methods are employed, with exhaustive cross-checks and validation. Approaches for reaching the ...
    • Toxicity of Quantum Dots and Cadmium Salt to Caenorhabditis elegans after Multigenerational Exposure 

      Contreras, Elizabeth Q.; Cho, Minjung; Zhu, Huiguang; Puppala, Hema L.; Escalera, Gabriela; Zhong, Weiwei; Colvin, Vicki L. (2013)
      To fully understand the biological and environmental impacts of nanomaterials requires studies that address both sublethal end points and multigenerational effects. Here, we use a nematode to examine these issues as they ...
    • A Transferable Model for Chromosome Architecture 

      Di Pierro, M.; Zhang, B.; Lieberman, Aiden E.; Wolynes, P.G.; Onuchic J.N. (2016)
      In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism driving the folding process remains unknown. We report a theoretical model for chromatin (Minimal Chromatin Model) that explains ...
    • Transition metal complexes of the naked pnictide elements 

      Whitmire, Kenton H. (2018)
      Even though transition metal compounds containing “naked” pnictide elements (E) have been known for many decades now, the chemistry of this interesting class of compounds continues to provide surprises and intellectual ...
    • Transition metal-free direct dehydrogenative arylation of activated C(sp3)–H bonds: synthetic ambit and DFT reactivity predictions 

      Lovato, Kaitlyn; Guo, Lirong; Xu, Qing-Long; Liu, Fengting; Yousufuddin, Muhammed; Ess, Daniel H.; Kürti, László; Gao, Hongyin (2018)
      A transition metal-free dehydrogenative method for the direct mono-arylation of a wide range of activated C(sp3)-H bonds has been developed. This operationally simple and environmentally friendly aerobic arylation ...
    • Transport in Supported Polyelectrolyte Brushes 

      Reznik, Carmen; Landes, Christy F. (2012)
      Functional polymers have a wide variety of applications ranging from energy storage to drug delivery. For energy storage applications, desirable material properties include low cost, high charge storage and/or mobility, ...
    • Transport mechanism in granular Ni deposited on carbon nanotubes fibers 

      Salvato, M.; Lucci, M.; Ottaviani, I.; Cirillo, M.; Tamburri, E.; Orlanducci, S.; Terranova, M.L.; Notarianni, M.; Young, C.C.; Behabtu, N.; Pasquali, M. (2012)
      We investigate the transport properties of granular nickel electrodeposited on carbon nanotube fibers by measuring the electrical resistance and the current voltage characteristics as a function of the temperature. The ...
    • Troika of single particle tracking programing: SNR enhancement, particle identification, and mapping 

      Shuang, Bo; Chen, Jixin; Kisley, Lydia; Landes, Christy F. (2014)
      Single particle tracking (SPT) techniques provide a microscopic approach to probe in vivo and in vitro structure and reactions. Automatic analysis of SPT data with high efficiency and accuracy spurs the development of SPT ...
    • Tunable optical tweezers for wavelength-dependent measurements 

      Hester, Brooke; Campbell, Gretchen K.; Lopez-Mariscal, Carlos; Filgueira, Carly Levin; Huschka, Ryan; Halas, Naomi J.; Helmerson, Kristian (2012)
      Optical trapping forces depend on the difference between the trap wavelength and the extinction resonances of trapped particles. This leads to a wavelength-dependent trapping force, which should allow for the optimization ...
    • Tunable Surface Properties of Aluminum Oxide Nanoparticles from Highly Hydrophobic to Highly Hydrophilic 

      Al-Shatty, Wafaa; Lord, Alex M.; Alexander, Shirin; Barron, Andrew R. (2017)
      The formation of materials with tunable wettability is important for applications ranging from antifouling to waterproofing surfaces. We report the use of various low-cost and nonhazardous hydrocarbon materials to tune the ...
    • Tunable Surface Properties of Aluminum Oxide Nanoparticles from Highly Hydrophobic to Highly Hydrophilic 

      Al-Shatty, Wafaa; Lord, Alex M.; Alexander, Shirin; Barron, Andrew R. (2017)
      The formation of materials with tunable wettability is important for applications ranging from antifouling to waterproofing surfaces. We report the use of various low-cost and nonhazardous hydrocarbon materials to tune the ...
    • Tuning the acoustic frequency of a gold nanodisk through its adhesion layer 

      Chang, Wei-Shun; Wen, Fangfang; Chakraborty, Debadi; Su, Man-Nung; Zhang, Yue; Shuang, Bo; Nordlander, Peter; Sader, John E.; Halas, Naomi J.; Link, Stephan (2015)
      To fabricate robust metallic nanostructures with top-down patterning methods such as electron-beam lithography, an initial nanometer-scale layer of a second metal is deposited to promote adhesion of the metal of interest. ...
    • Turning On and Off Photoinduced Electron Transfer in Fluorescent Proteins by π-Stacking, Halide Binding, and Tyr145 Mutations 

      Bogdanov, Alexey M.; Acharya, Atanu; Titelmayer, Anastasia V.; Mamontova, Anastasia V.; Bravaya, Ksenia B.; Kolomeisky, Anatoly B.; Lukyanov, Konstantin A.; Krylov, Anna I. (2016)
      Photoinduced electron transfer in fluorescent proteins from the GFP family can be regarded either as an asset facilitating new applications or as a nuisance leading to the loss of optical output. Photooxidation commonly ...
    • Two distinctive energy migration pathways of monolayer molecules on metal nanoparticle surfaces 

      Li, Jiebo; Qian, Huifeng; Chen, Hailong; Zhao, Zhun; Yuan, Kaijun; Chen, Guangxu; Miranda, Andrea; Guo, Xunmin; Chen, Yajing; Zheng, Nanfeng; Wong, Michael S.; Zheng, Junrong (2016)
      Energy migrations at metal nanomaterial surfaces are fundamentally important to heterogeneous reactions. Here we report two distinctive energy migration pathways of monolayer adsorbate molecules on differently sized metal ...
    • Two-Step Self-Assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release 

      Wickremasinghe, Navindee C.; Kumar, Vivek A.; Hartgerink, Jeffrey D. (2014)
      Progress in self-assembly and supramolecular chemistry has been directed toward obtaining macromolecular assemblies with higher degrees of complexity, simulating the highly structured environment in natural systems. One ...