Recent Submissions

  • Elucidating the correlations between cancer initiation times and lifetime cancer risks 

    Teimouri, Hamid; Kochugaeva, Maria P.; Kolomeisky, Anatoly B. (2019)
    Cancer is a genetic disease that results from accumulation of unfavorable mutations. As soon as genetic and epigenetic modifications associated with these mutations become strong enough, the uncontrolled tumor cell growth ...
  • Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation 

    Molkentine, Jessica M.; Fujimoto, Tara N.; Horvath, Thomas D.; Grossberg, Aaron J.; Garcia, Carolina J. Garcia; Deorukhkar, Amit; de la Cruz Bonilla, Marimar; Lin, Daniel; Samuel, Errol L.G.; Chan, Wai Kin; Lorenzi, Philip L.; Piwnica-Worms, Helen; Dantzer, Robert; Tour, James M.; Mason, Kathryn A.; Taniguchi, Cullen M. (2019)
    Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable ...
  • How to control single-molecule rotation 

    Simpson, Grant J.; García-López, Víctor; Daniel Boese, A.; Tour, James M.; Grill, Leonhard (2019)
    The orientation of molecules is crucial in many chemical processes. Here, we report how single dipolar molecules can be oriented with maximum precision using the electric field of a scanning tunneling microscope. Rotation ...
  • Geometric imaging of borophene polymorphs with functionalized probes 

    Liu, Xiaolong; Wang, Luqing; Li, Shaowei; Rahn, Matthew S.; Yakobson, Boris I.; Hersam, Mark C. (2019)
    A common characteristic of borophene polymorphs is the presence of hollow hexagons (HHs) in an otherwise triangular lattice. The vast number of possible HH arrangements underlies the polymorphic nature of borophene, and ...
  • Development of Functionalized Carbon Nano-Onions Reinforced Zein Protein Hydrogel Interfaces for Controlled Drug Release 

    Mamidi, Narsimha; González-Ortiz, Aldo; Lopez Romo, Irasema; Barrera, Enrique V. (2019)
    In the current study, poly 4-mercaptophenyl methacrylate-carbon nano-onions (PMPMA-CNOs = f-CNOs) reinforced natural protein (zein) composites (zein/f-CNOs) are fabricated using the acoustic cavitation technique. The ...
  • Nanoscale coupling of endocytic pit growth and stability 

    Lehmann, Martin; Lukonin, Ilya; Noé, Frank; Schmoranzer, Jan; Clementi, Cecilia; Loerke, Dinah; Haucke, Volker (2019)
    Clathrin-mediated endocytosis, an essential process for plasma membrane homeostasis and cell signaling, is characterized by stunning heterogeneity in the size and lifetime of clathrin-coated endocytic pits (CCPs). If and ...
  • Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation 

    Molkentine, Jessica M.; Fujimoto, Tara N.; Horvath, Thomas D.; Grossberg, Aaron J.; Garcia, Carolina J. Garcia; Deorukhkar, Amit; de la Cruz Bonilla, Marimar; Lin, Daniel; Samuel, Errol L.G.; Chan, Wai Kin; Lorenzi, Philip L.; Piwnica-Worms, Helen; Dantzer, Robert; Tour, James M.; Mason, Kathryn A.; Taniguchi, Cullen M. (2019)
    Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable ...
  • Geometric imaging of borophene polymorphs with functionalized probes 

    Liu, Xiaolong; Wang, Luqing; Li, Shaowei; Rahn, Matthew S.; Yakobson, Boris I.; Hersam, Mark C. (2019)
    A common characteristic of borophene polymorphs is the presence of hollow hexagons (HHs) in an otherwise triangular lattice. The vast number of possible HH arrangements underlies the polymorphic nature of borophene, and ...
  • Generalized method to design phase masks for 3D super-resolution microscopy 

    Wang, Wenxiao; Ye, Fan; Shen, Hao; Moringo, Nicholas A.; Dutta, Chayan; Robinson, Jacob T.; Landes, Christy F. (2019)
    Point spread function (PSF) engineering by phase modulation is a novel approach to three-dimensional (3D) super-resolution microscopy, with different point spread functions being proposed for specific applications. It is ...
  • Manganese deception on graphene and implications in catalysis 

    Ye, Ruquan; Dong, Juncai; Wang, Luqing; Mendoza-Cruz, Rubén; Li, Yilun; An, Peng-Fei; Yacamán, Miguel José; Yakobson, Boris I.; Chen, Dongliang; Tour, James M. (2018)
    Heteroatom-doped metal-free graphene has been widely studied as the catalyst for the oxygen reduction reaction (ORR). Depending on the preparation method and the dopants, the ORR activity varies ranging from a two-electron ...
  • STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy 

    Leach, David G.; Dharmaraj, Neeraja; Piotrowski, Stacey L.; Lopez-Silva, Tania L.; Lei, Yu L.; Sikora, Andrew G.; Young, Simon; Hartgerink, Jeffrey D. (2018)
    Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator ...
  • Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells 

    Moore, Amanda N.; Lopez Silva, Tania L.; Carrejo, Nicole C.; Origel Marmolejo, Carlos A.; Li, I-Che; Hartgerink, Jeffrey D. (2018)
    The design of materials for regenerative medicine has focused on delivery of small molecule drugs, proteins, and cells to help accelerate healing. Additionally, biomaterials have been designed with covalently attached ...
  • Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1–42) and Amyloid Beta(1–40) 

    Zheng, Weihua; Tsai, Min-Yeh; Wolynes, Peter G. (2017)
    Using a predictive coarse-grained protein force field, we compute and compare the free energy landscapes and relative stabilities of amyloid-β protein (1–42) and amyloid-β protein (1–40) in their monomeric and oligomeric ...
  • Resolving the NFκB Heterodimer Binding Paradox: Strain and Frustration Guide the Binding of Dimeric Transcription Factors 

    Potoyan, Davit A.; Bueno, Carlos; Zheng, Weihua; Komives, Elizabeth A.; Wolynes, Peter G. (2017)
    Many eukaryotic transcription factors function after forming oligomers. The choice of protein partners is a nonrandom event that has distinct functional consequences for gene regulation. In the present work we examine three ...
  • APE-Gen: A Fast Method for Generating Ensembles of Bound Peptide-MHC Conformations 

    Abella, Jayvee R.; Antunes, Dinler A.; Clementi, Cecilia; Kavraki, Lydia E. (2019)
    The Class I Major Histocompatibility Complex (MHC) is a central protein in immunology as it binds to intracellular peptides and displays them at the cell surface for recognition by T-cells. The structural analysis of bound ...
  • Magnesium controls aptamer-expression platform switching in the SAM-I riboswitch 

    Roy, Susmita; Hennelly, Scott P.; Lammert, Heiko; Onuchic, José N.; Sanbonmatsu, Karissa Y. (2019)
    Investigations of most riboswitches remain confined to the ligand-binding aptamer domain. However, during the riboswitch mediated transcription regulation process, the aptamer domain and the expression platform compete for ...
  • Metal-organic frameworks tailor the properties of aluminum nanocrystals 

    Robatjazi, Hossein; Weinberg, Daniel; Swearer, Dayne F.; Jacobson, Christian; Zhang, Ming; Tian, Shu; Zhou, Linan; Nordlander, Peter; Halas, Naomi J. (2019)
    Metal-organic frameworks (MOFs) and metal nanoparticles are two classes of materials that have received considerable recent attention, each for controlling chemical reactivities, albeit in very different ways. Here, we ...
  • Plasmon damping depends on the chemical nature of the nanoparticle interface 

    Foerster, Benjamin; Spata, Vincent A.; Carter, Emily A.; Sönnichsen, Carsten; Link, Stephan (2019)
    The chemical nature of surface adsorbates affects the localized surface plasmon resonance of metal nanoparticles. However, classical electromagnetic simulations are blind to this effect, whereas experiments are typically ...
  • The safe handling of bulk low-density nanomaterials 

    Gangoli, Varun Shenoy; Raja, Pavan M.V.; Esquenazi, Gibran Liezer; Barron, Andrew R. (2019)
    Nanomaterials, and in particular carbon nanotubes, possess a high surface area coupled with low density. This combination of properties renders a challenge in handling them safely, as they are susceptible to static charges, ...
  • Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level 

    Lin, Xingcheng; Kulkarni, Prakash; Bocci, Federico; Schafer, Nicholas P.; Roy, Susmita; Tsai, Min-Yeh; He, Yanan; Chen, Yihong; Rajagopalan, Krithika; Mooney, Steven M.; Zeng, Yu; Weninger, Keith; Grishaev, Alex; Onuchic, José N.; Levine, Herbert; Wolynes, Peter G.; Salgia, Ravi; Rangarajan, Govindan; Uversky, Vladimir; Orban, John; Jolly, Mohit Kumar (2019)
    Folded proteins show a high degree of structural order and undergo (fairly constrained) collective motions related to their functions. On the other hand, intrinsically disordered proteins (IDPs), while lacking a well-defined ...

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