Now showing items 111-116 of 116
Toll Mediated Infection Response Is Altered by Gravity and Spaceflight in Drosophila
(Public Library of Science, 2014)
Space travel presents unlimited opportunities for exploration and discovery, but requires better understanding of the biological consequences of long-term exposure to spaceflight. Immune function in particular is relevant ...
IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells
(John Wiley & Sons, Inc., 2014)
Chronic inflammation is associated with advanced prostate cancer (PCa), although the mechanisms governing inflammation-mediated PCa progression are not fully understood. PCa progresses to an androgen independent phenotype ...
Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis
The molecule known as SF2575 from Streptomyces sp. is a tetracycline polyketide natural product that displays antitumor activity against murine leukemia P388 in vivo. In the SF2575 biosynthetic pathway, SsfS6 has been ...
Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin
(American Society for Biochemistry and Molecular Biology, 2016)
Lignin is a combinatorial polymer comprising monoaromatic units that are linked via covalent bonds. Although lignin is a potential source of valuable aromatic chemicals, its recalcitrance to chemical or biological digestion ...
Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis
(Oxford University Press, 2014)
Several protein-targeted RNA aptamers have been identified for a variety of applications and although the affinities of numerous protein-aptamer complexes have been determined, the structural details of these complexes ...
Distinct Roles for Neuropilin1 and Neuropilin2 during Mouse Corneal Innervation
(Public Library of Science, 2012)
Trigeminal sensory innervation of the cornea is critical for protection and synthesis of neuropeptides required for normal vision. Little is known about axon guidance during mammalian corneal innervation. In contrast to ...