Now showing items 1-2 of 2
Adaptation of Enterococcus faecalis to Daptomycin Reveals an Ordered Progression to Resistance
(American Society for Microbiology, 2013)
With increasing numbers of hospital-acquired antibiotic resistant infections each year and staggering health care costs, there is a clear need for new antimicrobial agents, as well as novel strategies to extend their ...
Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance
(National Academy of Sciences, 2012)
In principle, evolutionary outcomes could be largely predicted if all of the relevant physicochemical variants of a particular protein function under selection were known and integrated into an appropriate physiological ...