Now showing items 54-73 of 116

    • Malaria Theranostics using Hemozoin-Generated Vapor Nanobubbles 

      Lukianova-Hleb, Ekaterina Y.; Lapotko, Dmitri O. (2014)
      Malaria remains a widespread and deadly infectious human disease, with increasing diagnostic and therapeutic challenges due to the drug resistance and aggressiveness of malaria infection. Early detection and innovative ...
    • Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior 

      Grindel, B.J.; Martinez, J.R.; Pennington, C.L.; Muldoon, M.; Stave, J.; Chung, L.W.; Farach-Carson, M.C. (2014)
      Perlecan/HSPG2, a large heparan sulfate (HS) proteoglycan, normally is expressed in the basement membrane (BM) underlying epithelial and endothelial cells. During prostate cancer (PCa) cell invasion, a variety of proteolytic ...
    • Measuring Competitive Fitness in Dynamic Environments 

      Razinkov, Ivan A.; Baumgartner, Bridget L.; Bennett, Matthew R.; Tsimring, Lev S.; Hasty, Jeff (2013)
      Most yeast genes are dispensable for optimal growth in laboratory cultures. However, this apparent lack of fitness contribution is difficult to reconcile with the theory of natural selection. Here we use stochastic modeling ...
    • Metabolic engineering of carbon and redox flow in the production of small organic acids 

      Thakker, Chandresh; Martínez, Irene; Li, Wei; San, Ka-Yiu; Bennett, George N. (2014)
      The review describes efforts toward metabolic engineering of production of organic acids. One aspect of the strategy involves the generation of an appropriate amount and type of reduced cofactor needed for the designed ...
    • Metabolic regulation of collagen gel contraction by porcine aortic valvular interstitial cells 

      Kamel, Peter I.; Qu, Xin; Geiszler, Andrew M.; Nagrath, Deepak; Harmancey, Romain; Taegtmeyer, Heinrich; Grande-Allen, K. Jane (2014)
      Despite a high incidence of calcific aortic valve disease in metabolic syndrome, there is little information about the fundamental metabolism of heart valves. Cell metabolism is a first responder to chemical and mechanical ...
    • Modeling delay in genetic networks: From delay birth-death processes to delay stochastic differential equations 

      Gupta, Chinmaya; López, José Manuel; Azencott, Robert; Bennett, Matthew R.; Josić, Krešimir; Ott, William (2014)
      Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and ...
    • Modular, Multi-Input Transcriptional Logic Gating with Orthogonal LacI/GalR Family Chimeras 

      Shis, David L.; Hussain, Faiza; Meinhardt, Sarah; Swint-Kruse, Liskin; Bennett, Matthew R. (2014)
      In prokaryotes, the construction of synthetic, multi-input promoters is constrained by the number of transcription factors that can simultaneously regulate a single promoter. This fundamental engineering constraint is an ...
    • Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells 

      Kim, Kyubo; Petrova, Youlia M.; Scott, Brenton L.; Nigam, Rupesh; Agrawal, Anurag; Evans, Christopher M.; Azzegagh, Zoulikha; Gomez, Alejandra; Rodarte, Elsa M.; Olkkonen, Vesa M.; Bagirzadeh, Rustam; Piccotti, Lucia; Ren, Binhui; Yoon, Joo-Heon; McNew, James A.; Adachi, Roberto; Tuvim, Michael J.; Dickey, Burton F. (2012)
      Airway mucin secretion and MC (mast cell) degranulation must be tightly controlled for homoeostasis of the lungs and immune system respectively. We found the exocytic protein Munc18b to be highly expressed in mouse ...
    • Nitrogen, biochar, and mycorrhizae: Alteration of the symbiosis and oxidation of the char surface 

      LeCroy, Chase; Masiello, Caroline A.; Rudgers, Jennifer A.; Hockaday, William C.; Silberg, Jonathan J. (2014)
      In some cases amending soil with biochar improves fertility, although the exact mechanisms through which biochar alters soil processes are not well understood. In other cases, however, biochar amendment can have no effect ...
    • A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland 

      Pradhan-Bhatt, Swati; Harrington, Daniel A.; Duncan, Randall L.; Farach-Carson, Mary C.; Jia, Xinqiao; Witt, Robert L. (2014)
      Objectives/Hypothesis: To create a novel model for development of a tissue-engineered salivary gland from human salivary gland cells that retains progenitor cell markers useful for treatment of radiation-induced xerostomia. ...
    • OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers 

      Monroig-Bosque, Paloma del C.; Shah, Maitri Y.; Fu, Xiao; Fuentes-Mattei, Enrique; Ling, Hui; Ivan, Cristina; Nouraee, Nazila; Huang, Beibei; Chen, Lu; Pileczki, Valentina; Redis, Roxana S.; Jung, Eun-Jung; Zhang, Xinna; Lehrer, Michael; Nagvekar, Rahul; Mafra, Ana Carolina P.; Monroig-Bosque, Maria del Mar; Irimie, Alexandra; Rivera, Carlos; Dumitru, Calin Dan; Berindan-Neagoe, Ioana; Nikonowicz, Edward P.; Zhang, Shuxing; Calin, George A. (2018)
      The pervasive role of microRNAs (miRNAs) in cancer pathobiology drives the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, meticulous screening strategies ...
    • p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines 

      Chang, Megan A.; Morgado, Micaela; Warren, Curtis R.; Hinton, Cimona V.; Farach-Carson, Mary C.; Delk, Nikki A. (2014)
      BACKGROUND: Bone marrow stromal cell (BMSC) paracrine factor(s) can induce apoptosis in bone metastatic prostate cancer (PCa) cell lines. However, the PCa cells that escape BMSC-induced apoptosis can upregulate cytoprotective ...
    • Periodic, Quasi-periodic and Chaotic Dynamics in Simple Gene Elements with Time Delays 

      Suzuki, Yoko; Lu, Mingyang; Ben-Jacob, Eshel; Onuchic, José N. (2016)
      Regulatory gene circuit motifs play crucial roles in performing and maintaining vital cellular functions. Frequently, theoretical studies of gene circuits focus on steady-state behaviors and do not include time delays. In ...
    • Perlecan-Containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-Canalicular System 

      Wang, Bin; Lai, Xiaohan; Price, Christopher; Thompson, William R.; Li, Wen; Quabili, Tonima R.; Tseng, Wei-Ju; Liu, Xiaowei Sherry; Zhang, Hong; Pan, Jun; Kirn-Safran, Catherine B.; Farach-Carson, Mary C.; Wang, Liyun (2014)
      The pericellular matrix (PCM), a thin coating surrounding nearly all mammalian cells, plays a critical role in many cell-surface phenomena. In osteocytes, the PCM is believed to control both “outside-in” (mechanosensing) ...
    • Peroxisomes Are Required for Lipid Metabolism and Muscle Function in Drosophila melanogaster 

      Faust, Joseph E.; Manisundaram, Arvind; Ivanova, Pavlina T.; Milne, Stephen B.; Summerville, James B.; Brown, H. Alex; Wangler, Michael; Stern, Michael; McNew, James A. (2014)
      Peroxisomes are ubiquitous organelles that perform lipid and reactive oxygen species metabolism. Defects in peroxisome biogenesis cause peroxisome biogenesis disorders (PBDs). The most severe PBD, Zellweger syndrome, is ...
    • Pierced Lasso Bundles Are a New Class of Knot-like Motifs 

      Haglund, Ellinor; Sulkowska, Joanna I.; Noel, Jeffrey K.; Lammert, Heiko; Onuchic, José N.; Jennings, Patricia A. (2014)
      A four-helix bundle is a well-characterized motif often used as a target for designed pharmaceutical therapeutics and nutritional supplements. Recently, we discovered a new structural complexity within this motif created ...
    • Plant Peroxisomes: Biogenesis and Function 

      Hu, Jianping; Baker, Alison; Bartel, Bonnie; Linka, Nicole; Mullen, Robert T.; Reumann, Sigrun; Zolman, Bethany K. (2012-06)
      Peroxisomes are eukaryotic organelles that are highly dynamic both in morphology and metabolism. Plant peroxisomes are involved in numerous processes, including primary and secondary metabolism, development, and responses ...
    • Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors 

      Lukianova-Hleb, Ekaterina Y.; Ren, Xiaoyang; Townley, Debra; Wu, Xiangwei; Kupferman, Michael E. (2012)
      The resistance of residual cancer cells after oncological resection to adjuvant chemoradiotherapies results in both high recurrence rates and high non-specific tissue toxicity, thus preventing the successful treatment of ...
    • The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin 

      Sjodt, Megan; Macdonald, Ramsay; Spirig, Thomas; Chan, Albert H.; Dickson, Claire F.; Fabian, Marian; Olson, John S.; Gell, David A.; Clubb, Robert T. (2016)
      Staphylococcus aureus is a medically important bacterial pathogen that, during infections, acquires iron from human hemoglobin (Hb). It uses two closely related iron-regulated surface determinant (Isd) proteins to capture ...