Now showing items 1-5 of 5

    • Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis 

      Lipper, Colin H.; Paddock, Mark L.; Onuchic, José N.; Mittler, Ron; Nechushtai, Rachel; Jennings, Patricia A. (2015)
      Iron-sulfur cluster biogenesis is executed by distinct protein assembly systems. Mammals have two systems, the mitochondrial Fe-S cluster assembly system (ISC) and the cytosolic assembly system (CIA), that are connected ...
    • Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1 

      Tamir, Sagi; Rotem-Bamberger, Shahar; Katz, Chen; Morcos, Faruck; Hailey, Kendra L.; Zuris, John A.; Wang, Charles; Conlan, Andrea R.; Lipper, Colin H.; Paddock, Mark L.; Mittler, Ron; Onuchic, José N.; Jennings, Patricia A.; Friedler, Assaf; Nechushtai, Rachel (2014)
      Life requires orchestrated control of cell proliferation, cell maintenance, and cell death. Involved in these decisions are protein complexes that assimilate a variety of inputs that report on the status of the cell and ...
    • Interactions between mitoNEET and NAF-1 in cells 

      Karmi, Ola; Holt, Sarah H.; Song, Luhua; Tamir, Sagi; Luo, Yuting; Bai, Fang; Adenwalla, Ammar; Darash-Yahana, Merav; Sohn, Yang-Sung; Jennings, Patricia A.; Azad, Rajeev K.; Onuchic, José N.; Morcos, Faruck; Nechushtai, Rachel; Mittler, Ron (2017)
      The NEET proteins mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1) are required for cancer cell proliferation and resistance to oxidative stress. NAF-1 and mNT are also implicated in a number of other ...
    • NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth 

      Sohn, Yang-Sung; Tamir, Sagi; Song, Luhua; Michaeli, Dorit; Matouk, Imad; Conlan, Andrea R.; Harir, Yael; Holt, Sarah H.; Shulaev, Vladimir; Paddock, Mark L.; Hochberg, Abraham; Cabanchick, Ioav Z.; Onuchic, José N.; Jennings, Patricia A.; Nechushtai, Rachel; Mittler, Ron (2013)
      Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy ...
    • Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates 

      Inupakutika, Madhuri A.; Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A.; Onuchic, José N.; Azad, Rajeev K.; Padilla, Pamela; Mittler, Ron (2017)
      NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the “NEET” motif. They are involved in the regulation of iron and reactive ...