Now showing items 1-3 of 3
Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent
A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively ...
Total Synthesis of Myceliothermophins C, D and E
The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three ...
Total Synthesis and Structural Revision of Antibiotic CJ-16,264
The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-Alder reaction that casted stereoselectively ...