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Total Synthesis of Myceliothermophins C, D and E
The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three ...
Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent
A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively ...