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Total Synthesis and Structural Revision of Antibiotic CJ-16,264
The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-Alder reaction that casted stereoselectively ...
Total Synthesis of Myceliothermophins C, D and E
The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three ...
Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent
A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively ...
The endeavor of total synthesis and its impact on chemistry, biology and medicine
The synthesis of urea in 1828 set in motion the discipline of organic synthesis in general and of total synthesis in particular, the art and science of synthesizing natural products, the molecules of living nature. Early ...
Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory
Synthetic organic chemists have the power to replicate some of the most intriguing molecules of living nature in the laboratory and apply their developed synthetic strategies and technologies to construct variations of ...